Participating Companies

Amarin Corporation [AMRN] $2,044 MM MCap
Com­mer­cial­iz­ing Vas­ce­pa, the first and on­ly pure EPA ome­ga-3 fat­ty acid ap­proved to low­er trig­lyc­eride lev­els in adults. Pre­sent­ed (+) da­ta from RE­DUCE-IT CV Out­comes trial at AHA. First 9mo rev’s of 2020 ~$450M. [more in­for­ma­tion]
Arbor Biotechnologies
An ear­ly-stage life sci­ences com­pany pi­oneer­ing the next-gen­er­a­tion of ge­net­ic medicines. With the most ex­ten­sive li­brary of CRIS­PR nu­cleas­es in the in­dus­try, a deep bench of world-class foun­ders (in­clud­ing gene edit­ing pi­oneer Feng Zhang) and sci­en­tif­ic ad­vi­sors, and a lead­er­ship team with a proven track re­cord of de­vel­op­ing nov­el plat­forms and ther­a­peu­tics, Ar­bor is well-po­si­tioned to de­vel­op cu­ra­tive ge­net­ic medicines for all pa­tients with ge­net­ic dis­eas­es. [more in­for­ma­tion]
Biohaven Pharmaceuticals, Inc [BHVN] $8,955 MM MCap
NURTEC® ODT ap­proved in 1Q20. NURTEC® ODT for pre­ven­ta­tive treat­ment of mi­graine ap­proved 1Q2021. 4Q21 exp. Ph3 MSA read­out. [more in­for­ma­tion]
Clerio Vision, Inc.
Nov­el oph­thalmic tech­nol­o­gy to treat re­frac­tive er­ror ad­dress­ing mul­ti-bil­lion mar­kets in con­tact lens­es (pres­by­opia) and corneal vi­sion cor­rec­tion (non sur­g­i­cal fla­p­less las­er so­lu­tion). Based on No­bel Prize win­n­ing fem­to-se­cond las­er tech­nol­o­gy de­vel­oped by Bausch & Lomb and the Uni­ver­si­ty of Roch­ester. [more in­for­ma­tion]
ESSA Pharma Inc. [EPIX] $251 MM MCap
In Ph1b with a small molecule drug tar­get­ing the n-ter­mi­nal do­main of the an­dro­gen re­cep­tor. Po­ten­tial for treat­ment post-cur­rent AR ther­a­pies and in com­bi­na­tion in ear­li­er lines. Pfiz­er par­ti­ci­pat­ed in most re­cent fundrais­ing. Re­cent col­lab­o­ra­tions with Bay­er, Astel­las, and Janssen to eval­u­ate com­bi­na­tions with their main drug can­di­date EPI-7386. [more in­for­ma­tion]
Landos Biopharma [LABP] $617 MM MCap
Pipe­line tar­gets nov­el im­munometabolic path­ways, in­clud­ing LAN­CL2, NL­RX1 and PLXD­C2. Lead as­set omi­lan­cor is a nov­el, oral, gut-re­strict­ed small molecule ther­a­peu­tic can­di­date for the treat­ment of ul­cer­a­tive coli­tis (com­plet­ed Ph2), Crohn’s dis­ease (Ph2) and Eosinophil­ic Esophagi­tis that tar­gets the LAN­CL2 path­way [more in­for­ma­tion]
Marker Therapeutics [MRKR] $149 MM MCap
Fo­cused on de­vel­op­ing next-gen­er­a­tion T cell-based im­munother­a­pies for the treat­ment of he­ma­to­log­i­cal ma­lig­nan­cies and solid tu­mor in­di­ca­tions. Mark­er's cell ther­a­py tech­nol­o­gy is based on the se­lec­tive ex­pan­sion of non-en­gi­neered, tu­mor-spe­cif­ic T cells that rec­og­nize tu­mor as­so­ci­at­ed anti­gens and kill tu­mor cells ex­press­ing those tar­gets. [more in­for­ma­tion]
Minerva Biotechnologies
im­munother­a­pies for can­cer and cel­lu­lar ther­a­pies in re­gen­er­a­tive medicine. First-in-hu­man trial of huM­NC2-CAR44, a CAR T ther­a­py tar­get­ing MUC1* in me­tastat­ic breast can­cers in pa­tients with MUC1* re­ac­tive tu­mors. IND for 1XX ver­sion of this CAR T, which great­ly in­creas­es per­sis­tence and recog­ni­tion of low anti­gen den­si­ty cells will be filed in 2021. [more in­for­ma­tion]
Monte Rosa Therapeutics [GLUE] $1,495 MM MCap
Next-gen­er­a­tion molec­u­lar glue-based tar­get­ed pro­tein degra­da­tion plat­form de­vel­op­ing small molecule ther­a­peu­tics that se­lec­tive­ly de­grade dis­ease-caus­ing pro­teins. Tar­get­ing the un­drug­gable pro­teome in on­col­o­gy and non-on­col­o­gy in­di­ca­tions via AI based de­gron pre­dic­tion. Ex­ten­sive in vi­vo da­ta to date has de­mon­s­trat­ed po­tent an­ti-tu­mor ac­tiv­i­ty. Lead pro­gram fo­cused on GSP­T1, a key reg­u­la­tor and vul­n­er­a­bil­i­ty of Myc-in­duced trans­la­tio­n­al ad­dic­tion. DC se­lec­tion for lead pro­gram ex­pect­ed in 2021. [more in­for­ma­tion]
Neoleukin Therapeutics [NLTX] $342 MM MCap
Lead prod­uct can­di­date, NL-201, is a de no­vo pro­tein de­signed to mim­ic the ther­a­peu­tic ac­tiv­i­ty of IL-2 and IL-15 for the treat­ment of can­cer. NL-201 is de­signed to elim­i­nate bind­ing to the al­pha sub­u­nit of the IL-2/CD25 re­cep­tor while main­tain­ing high-affini­ty bind­ing to the be­ta and gam­ma sub­u­nits. [more in­for­ma­tion]
Photocure ASA [PHO:OS] NKr2,914 MM MCap
Rev­enue-gen­er­at­ing urol­o­gy-fo­cused com­pany. Lead prod­uct, Hexvix®/Cysview® im­proves de­tec­tion of blad­der can­cer un­der blue light cys­tos­copy (BLC), which can re­duce dis­ease re­cur­rence and pro­gres­sion rates. Hexvix®/Cysview® is in­clud­ed in clin­i­cal consen­sus guide­lines and re­mains on a strong growth path. Rev­enues in 2020 to­taled $31M. Re­cent­ly suc­cess­ful­ly launched the Eu­ro­pean Hexvix op­er­a­tions, con­soli­dat­ing the Com­pany’s prod­uct franchise glob­al­ly. [more in­for­ma­tion]
Ryvu Therapeutics [RVU:WAR]
De­vel­op­er of tar­get­ed on­col­o­gy ther­a­pies in­clud­ing he­ma­tol­o­gy/solid tu­mors. RVU120 is whol­ly-owned first-in-class oral CD­K8/19 in­hibi­tor in Phase I for AML/MDS Small molecule, syn­thet­ic lethal­i­ty plat­form in pre-clin­i­cal de­vel­op­ment in­clud­ing nov­el tar­gets WRN and PRMT5. [more in­for­ma­tion]
Treos Bio Limited
Pipe­line in­cludes per­so­n­al­ized + off-the-shelf ther­a­pies for mul­ti­ple solid can­cers and an IND-ready 2nd gen­er­a­tion COVID T-cell vaccine. Their lead pro­grams in­clude treat­ment for MSS col­orec­tal can­cer, with strong Ph1/2 re­sults, and clin­i­cal col­lab­o­ra­tions with Roche and Mayo Clin­ic. [more in­for­ma­tion]
Vaccitech Plc [VACC] $566 MM MCap
Pro­pri­e­tary ChA­dOx (prime) and MVA (boost) tech­nol­o­gy plat­form in­duces and main­tains CD8+ T-cells at the max­i­mum lev­els pub­lished to date. Ph1/2 da­ta for HPV and HBV im­munother­a­pies ex­pect­ed 2H20. En­cour­ag­ing pros­tate can­cer, 5T4 im­munother­a­peu­tic da­ta re­cent­ly re­leased. Ph1/2 NS­CLC MAGE-NYE­SO im­munother­a­peu­tic en­ters clin­ic in Q1 2021. ChA­dOx COVID-19 vaccine out-li­censed to Ox­ford Uni/As­traZene­ca with post-pan­dem­ic rev­enue stream. $150M fund­ing at Jen­n­er In­sti­tute and com­pany raised $48M since for­ma­tion [more in­for­ma­tion]
Werewolf Therapeutics [HOWL] $473 MM MCap
Were­wolf Ther­a­peu­tics, Inc. is an in­no­va­tive bio­phar­ma­ceu­ti­cal com­pany pi­oneer­ing the de­vel­op­ment of ther­a­peu­tics en­gi­neered to sti­m­u­late the body’s im­mune sys­tem for the treat­ment of can­cer. [more in­for­ma­tion]