Participating Companies


Affimed N.V. [AFMD] US$349 MM MCap
NK cell en­gager AFM13 (CD30/CD16A) to en­ter a Phase 2 reg­is­tra­tion study in CD30-pos­i­tive pe­ripher­al T cell lym­pho­ma and an in­vesti­ga­tor-spon­sored study by MDACC of AFM13 com­bined with al­lo­gene­ic NK cells in re­lapsed/re­frac­to­ry CD30-pos­i­tive lym­pho­ma. [more in­for­ma­tion]
Alloplex Biotherapeutics
Our lead on­col­o­gy pro­gram us­es pro­pri­e­tary leuko­cyte ac­ti­va­tor cell (LAC) lines, which are en­gi­neered from a paren­tal tu­mor cell line, to spe­cif­i­cal­ly en­gage and ac­ti­vate pe­ripher­al blood mononu­clear cells (PBMC) through through na­tive re­cep­tors. [more in­for­ma­tion]
Aptorum Group [APM] US$105 MM MCap
Ap­to­rum is Hong Kong based, US list­ed com­pany (Mcap $100m) fo­cused on gen­er­at­ing late stage clin­i­cal can­di­dates by de­vel­op­ing al­ready ap­proved drugs for new or­phan in­di­ca­tions, as well as in­fec­tious dis­eas­es. Pipe­line – • SACT-1 for Neu­roblas­to­ma – ph2/3 trial planned for 2H’20 • SACT-COV­19 – COVID-19 treat­ment - pre­clin­i­cal [more in­for­ma­tion]
BerGenBio [BGBIO:OS] NKr3,469 MM MCap
De­vel­op­ing first-in-class se­lec­tive Axl ki­nase in­hibi­tors for liquid and solid can­cers, lead can­di­date is bem­cen­tinib (BG­B324) in four com­pany-spon­sored trials. [more in­for­ma­tion]
Bioasis Technologies, Inc. [BTI:CA] Can$23 MM MCap
is a bio­phar­ma­ceu­ti­cal com­pany de­vel­op­ing the xB3 ™ plat­form, a pro­pri­e­tary tech­nol­o­gy for the de­liv­ery of ther­a­peu­tics across the blood brain bar­ri­er and the treat­ment of CNS di­s­or­ders in ar­eas of high un­met med­i­cal need, in­clud­ing brain can­cers and neu­rode­gen­er­a­tive dis­eas­es. [more in­for­ma­tion]
BioXcel Therapeutics, Inc. [BTAI] US$1,080 MM MCap
BX­CL501 (sublin­gual dexmede­to­mi­dine): Phase 3 trials on­go­ing for the acute treat­ment of ag­i­ta­tion in pa­tients with schi­zophre­nia (SERENI­TY I) and bipo­lar di­s­or­der (SERENI­TY II). Phase 1b/2 trial (TRAN­QUIL­I­TY) on­go­ing for the acute treat­ment of ag­i­ta­tion as­so­ci­at­ed with ge­ri­a­tric de­men­tia. [more in­for­ma­tion]
Candesant Biomedical
Can­de­sant Biomed­i­cal is de­vel­op­ing a com­pelling prod­uct to un­lock the po­ten­tial of the sweat con­trol mar­ket. Fur­ther, the prod­uct will pro­vide a great val­ue to the con­sumer with an eco­nom­ic in­cen­tive to the treat­ing physi­cians. [more in­for­ma­tion]
CASI Pharmaceuticals Inc. [CASI] US$242 MM MCap
Launched EVOMELA® (mel­pha­lan for in­jec­tion, mul­ti­ple myelo­ma) in Au­gust 2019, on­ly mel­pha­lan com­mer­cial­ly avai­l­able in Chi­na; ad­vanc­ing de­vel­op­ment of an­ti-CD19 T-cell ther­a­py (CNC­T19) in B-NHL and B-ALL and an­ti-CD38 mAb (CID-103) in mul­ti­ple myelo­ma, fo­cused on be­com­ing Chi­na’s ma­jor he­ma­tol­o­gy on­col­o­gy com­pany; [more in­for­ma­tion]
Cernostics, Inc.
De­vel­op­er of tis­sue-based di­ag­nos­tic test de­signed to quan­ti­fy the com­plex­i­ty of the tis­sue sys­tem. The com­pany's di­ag­nos­tic test unique­ly an­a­lyzes whole slide dig­i­tal im­ages with mul­ti­plexed flu­o­res­cence, pro­vid­ing physi­cians and pa­tients with in­di­vi­d­u­al­ized, ac­tion­able in­for­ma­tion to im­prove out­comes and re­duce the in­ci­dence and mor­tal­i­ty of can­cer. [more in­for­ma­tion]
CerSci Therapeutics
De­vel­op­ing a new gen­er­a­tion of non-opi­oid medicines to treat acute post-op­er­a­tive and chron­ic neu­ro­path­ic pain. Lead pro­gram in Phase 1 (MAD/SAD/Food Ef­fect), CT-044, tar­get­ing re­ac­tive spe­cies that cause neu­ro­n­al ion chan­nel hy­per-sen­si­ti­za­tion, known to trig­ger pain. [more in­for­ma­tion]
Cognition Therapeutics
Cog­ni­tion’s lead can­di­date, CT1812 (Elay­ta™), is a nov­el first-in-class, oral­ly avai­l­able small molecule that has shown the po­ten­tial in ini­tial clin­i­cal studies to nor­mal­ize pro­tein traf­fick­ing and lipid metabolism path­ways that are dis­rupt­ed in Alzheimer’s dis­ease and to al­low the pro­tec­tion and res­to­ra­tion of sy­naps­es. [more in­for­ma­tion]
Engage Therapeutics
En­gage Ther­a­peu­tics is fo­cused on bring­ing pa­tients with epilep­sy suf­fer­ing from un­con­trolled seizures what could be the first res­cue treat­ment with the po­ten­tial to stop their seizures. One in three of those peo­ple have what is con­sid­ered re­frac­to­ry epilep­sy with un­con­trolled seizures, as one or more an­ti-epilep­tic drugs has not worked for them. [more in­for­ma­tion]
Exicure [XCUR] US$207 MM MCap
Ex­i­cure en­tered in­to a col­lab­o­ra­tion with Al­ler­gan Phar­ma­ceu­ti­cals In­ter­na­tio­n­al Limit­ed in late 2019 and is now ac­tive­ly en­gaged in pre­clin­i­cal re­search and dis­cov­ery in two clin­i­cal pro­grams re­lat­ed to the treat­ment of hair loss di­s­or­ders. [more in­for­ma­tion]
Faraday Pharmaceuticals
El­e­men­tal re­duc­ing agents for crit­i­cal care treat­ment to pre­vent car­di­ac and skele­tal mus­cle loss: lead can­di­date FDY-5301 Ph 3 (piv­o­tal) to ini­ti­ate mid-2020 for reper­fu­sion in­jury fol­low­ing heart at­tack (AMI); da­ta ear­ly 2023. SPA sub­mis­sion re­ceived by FDA Jan 22, 2020 and ini­tial feed­back re­ceived Feb 2020 - Type A meet­ing re­quest, like­ly in April 2020. Sig­ni­f­i­cant ad­di­tio­n­al treat­ment ap­pli­ca­tions with limit­ed to no com­pe­ti­tion. $57M raised to date from Arch Ven­ture Part­n­ers, Po­laris Part­n­ers, WRF, Osa [more in­for­ma­tion]
Heidelberg Pharma AG [HPHA:DB] €144 MM MCap
Hei­del­berg Phar­ma AG (WL6, Frank­furt Stock Exchange), based in La­den­burg, Ger­many, is a lead­ing biotech com­pany pi­oneer­ing the use of its AT­AC (Anti­body Tar­get­ed Amanitin Con­ju­gate) plat­form to de­vel­op nov­el can­cer treat­ments with a unique mode of ac­tion ef­fec­tive at spe­cif­i­cal­ly killing both in­ac­tive and di­vid­ing can­cers cells and over­com­ing tu­mour re­sis­tance mech­anisms. [more in­for­ma­tion]
Inventiva Pharma [IVA:PA] €437 MM MCap
The com­pany is fo­cused on de­vel­op­ing its prod­uct can­di­date, lan­i­fi­branor, for the treat­ment of pa­tients with non-al­co­holic stea­to­he­p­ati­tis, or NASH, a dis­ease for which there are cur­rent­ly no ap­proved ther­a­pies. The com­pany is al­so in­volved in de­vel­op­ing a port­fo­lio of pre-clin­i­cal ther­a­py pro­grams. [more in­for­ma­tion]
Landos Biopharma
Based on ex­ten­sive pre­clin­i­cal studies, Lan­dos has vali­dat­ed a unique mech­anism of ac­tion in­volv­ing LAN­CL2 that ex­erts po­tent an­ti-in­flam­ma­to­ry ef­fects with an out­s­tand­ing safe­ty pro­file. Lead as­set BT-11 Phase 2 in­ter­im read out in mid-2020 in UC. [more in­for­ma­tion]
Lineage Cell Therapeutics [LCTX] US$118 MM MCap
Cell ther­a­py com­pany with 3 cl­ni­cal pro­grams 1) OpRe­gen, an RPE tran­s­plant ther­a­py in Ph1/2a de­vel­op­ment for the treat­ment of dry-AMD. 2) OPC1, an oli­go­den­dro­cyte pro­gen­i­tor cell ther­a­py for acute spi­nal cord in­juries with Or­phan and RMAT desig­na­tions. 3) VAC2, an al­lo­gene­ic can­cer im­munother­a­py of anti­gen-pre­sent­ing den­drit­ic cells cur­rent­ly in a Ph 1 for NS­CLC con­duct­ed by CRUK. [more in­for­ma­tion]
NervGen Pharma [NGENF] US$51 MM MCap
Nerv­Gen Phar­ma is a de­vel­op­ing nov­el ther­a­peu­tics for pa­tients suf­fer­ing from med­i­cal con­di­tions re­lat­ed to nerve da­m­age sus­tained as a re­sult of (i) in­jury, such as in spi­nal cord in­jury, or (ii) neu­rode­gen­er­a­tive dis­ease, such as MS or Alzheimer's dis­ease. [more in­for­ma­tion]
Neurana Pharmaceuticals
The pri­mary ob­jec­tive of the study was to as­sess the ef­fi­ca­cy of vari­ous dai­ly dos­es of tolperi­sone to de­ter­mine the dose to be used for the planned Phase 3 clin­i­cal pro­gram. Giv­en the pos­i­tive re­sults of the STAR Study, Neu­ra­na plans to conduct an end-of-Phase 2 meet­ing with the FDA in the first quar­ter of 2020 and ini­ti­ate Phase 3 clin­i­cal studies of tolperi­sone lat­er in 2020. [more in­for­ma­tion]
NeuroRx
De­vel­op­ing the first Glx tar­get­ed an­tide­pres­sant to ad­dress sui­ci­dal­i­ty in bipo­lar de­pres­sion. Lead can­di­date, NRX-101 is in Phase 2b/3 de­vel­op­ment, ini­ti­at­ed in Ju­ly 2019 (Break­through, SPA and Fast Track by FDA) for Se­vere Bipo­lar De­pres­sion in pts w Acute Sui­ci­dal Idea­tion and Be­havior. Re­port­ed Phase 2 ef­fi­ca­cy and safe­ty da­ta for NRX-011 in De­cem­ber 2018. [more in­for­ma­tion]
NexImmune, Inc.
Mul­ti-anti­gen-spe­cif­ic T cell ther­a­py. Syn­thet­ic nano­par­ti­cles de­c­o­rat­ed w a com­bo of mul­ti­ple tu­mor rel­e­vant anti­gens and co-sti­m­u­la­to­ry sig­nals en­gag­ing di­rect­ly w tar­get­ed T cells. Two Ph 1's on­go­ing. [more in­for­ma­tion]
NorthSea Therapeutics
First-in class, oral, struc­tu­ral­ly en­gi­neered fat­ty acids [SE­FAs] ad­dress­ing NASH and as­so­ci­at­ed metabolic di­s­or­ders via unique tar­get­ing of path­ways reg­u­lat­ing metabolism, oxida­tive stress, in­flam­ma­tion, and fi­bro­sis. $40m Se­ries B (Jan 2020) with ven­Bio Part­n­ers (lead) and Sofin­no­va In­vest­ments. [more in­for­ma­tion]
Palladio Biosciences
De­vel­op­er of nov­el ther­a­peu­tics in­tend­ed to de­vel­op medicines for or­phan drug dis­eas­es of the kid­ney. The com­pany's of­fer­ings in­clude de­vel­op­ing treat­ments for Po­ly­cys­tic Kid­ney Dis­ease (PKD) which cause nu­mer­ous fluid-filled cysts to grow in both kid­neys, en­abling doc­tors to pre­vent the pro­gres­sion of PKD. [more in­for­ma­tion]
PharmaMar SA [PHM:ES]
Yon­delis (soft tis­sue sar­co­ma and ovarian can­cer) com­mer­cial­ized with di­rect sales-force in EU and part­n­er­ship in US with Janssen. Signed li­cens­ing agree­ment with Jazz Phar­ma for Lur­binecte­din in the US - up­front pay­ment of $200M, $100mm on ap­pro­va­land up to $550M sales mile­s­tones. Jazz to launch Zepzel­ca in US Ju­ly 2020. [more in­for­ma­tion]
Rapt Therapeutics [RAPT] US$665 MM MCap
Our lead on­col­o­gy drug can­di­date, FLX475, reached the clin­ic in just two and a half years, and our lead in­flam­ma­tion drug can­di­date, RP­T193, en­tered the clin­ic in Au­gust 2019. [more in­for­ma­tion]
Ryvu Therapeutics [RVU:WAR]
Po­ten­tial first in class CD­K8 in­hibi­tor for leukemias, lym­pho­mas, and solid tu­mors in Ph1b in AML and high-risk MDS, PIM/FLT3 ki­nase in­hibi­tor in Ph 1/2 in AML (part­nered w Me­nari­ni). Da­ta in 2020. Ear­ly stage pipe­line ad­dress­ing emerg­ing solid tu­mor tar­gets. [more in­for­ma­tion]
Secarna Pharmaceuticals GmbH
Se­car­na's unique­ly ef­fi­cient LNA­plus™ dis­cov­ery pro­cess is fu­eled by their pro­pri­e­tary and stream­lined Oli­go­fy­er™ bioin­for­mat­ics sys­tems large in-house cell li­brary and own in vit­ro screen­ing as­says. [more in­for­ma­tion]
Sol-Gel Technologies Ltd. [SLGL] US$192 MM MCap
Com­mer­cial­iz­ing brand­ed gener­ic top­i­cal drug prod­ucts (skin dis­eas­es). Two pos­i­tive Phase 3 pro­grams in rosacea and acne, with NDAs ex­pect­ed in 1H20 and 2H20, re­spec­tive­ly. Ad­di­tio­n­al brand­ed pipe­line as­sets in­clude SGT-210, er­lo­tinib, for the treat­ment of punc­tu­ate pal­mo­plan­tar ker­a­to­der­ma, and pre­clin­i­cal as­set tap­i­narof and rof­lu­mi­last. Sol-Gel al­so has rev­enue from sev­er­al gener­ic col­lab­o­ra­tions. [more in­for­ma­tion]
Targovax [TRVX:OS] NKr510 MM MCap
Pre­lim­i­nary Ph1b da­ta of OV ON­COS-102+che­mo in me­sothe­lio­ma re­sults: com­bo mPFS=8.4 mos. vs. con­trol mPFS=6.8 mos.; 1L pts mPFS-8.9 mos. Up­com­ing mile­s­tones: up­dat­ed clin­i­cal & im­mune da­ta in Ph2 me­sothe­lio­ma (1H20); pre­clin­i­cal da­ta on next-gen OV w/ dou­ble trans­genes (1H20); and clin­i­cal da­ta from Ph1 me­lano­ma study, part 2 with ex­tend­ed dos­ing (2H20). [more in­for­ma­tion]
Vaccitech Limited
Pro­pri­e­tary ChA­dOx (prime) and MVA (boost) tech­nol­o­gy plat­form in­duces and main­tains CD8+ T-cells at the max­i­mum lev­els pub­lished to date. Ph1/2 for HPV and HBV im­munother­a­pies ini­ti­at­ing 1H20. Two can­cer im­munother­a­py pro­grams (per­so­n­al­ized vaccine and MAGE-NYE­SO ther­a­peu­tics) en­ter clin­ic in 2020. Two ChA­dOx1 vaccines for coro­n­avirus­es with Ox­ford Univ fund­ed by CEPI – COVID-19 (an­nounced 3/10/20) and MERS (Ph.1 com­plete). $150M fund­ing at Jen­n­er In­sti­tute and com­pany raised $48M since for­ma­tion in 2016 [more in­for­ma­tion]
Vedanta Biosciences
De­vel­op­ing an in­no­va­tive class of ther­a­pies that mo­d­u­late path­ways of in­ter­ac­tion be­tween the hu­man mi­cro­biome and the host im­mune sys­tem. Ve­dan­ta Bio­s­ciences was co-found­ed by PureTech and a group of world renowned ex­perts in im­munol­o­gy and mi­cro­bi­ol­o­gy. [more in­for­ma­tion]