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ZIOPHARM Oncology Inc: The company is focused on the development of two platform technologies designed to deliver safe, effective and scalable cell- and viral-based therapies for the treatment of multiple cancer types: (1) Controlled IL-12 for turning cold tumors hot and (2) Sleeping Beauty (SB) a non-viral approach to genetically modifying cells with significantly shortened manufacturing and lower COGS. Plan to submit an IND to evaluate SB-modified TCRs targeting neoantigens to treat solid tumors in Q4 2018 followed by enrollment of patients at the NCI beginning in 2019. Currently enrolling patients in a phase 1 trials of Ad-RTS-hIL-12 as monotherapy and in combination with OPDIVO for the treatment of rGBM.
Based in...
US - New England
Clinical Stage
Phase l or ll
Disease Space
Public, USA
Market Cap
500MM - 1B
Therapeutic Modalities
Cell Therapy, Platform Technology
1 1st Ave
Charlestown, MA 02129
United States

Company Participants at Solebury Trout CEO & Investor Ski Conference 2020

  • Laurence Cooper, MD, PhD, CEO

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Top 10 Holders of ZIOPHARM Oncology, Inc.

Institution OS (%) Position Mkt Val ($MM) Source Filing Date
MSD Partners LP 9.33 15,151,516 48.41 13F 2020-03-31
The Vanguard Group, Inc. 9.28 15,075,770 48.17 Funds 2020-05-31
Vanguard Group, Inc. (Subfiler) 8.99 14,593,843 46.63 13F 2020-03-31
Miller Value Partners LLC 7.92 12,857,035 41.08 13F 2020-03-31
Discovery Capital Management LLC 5.88 9,542,760 30.49 13F 2020-03-31
White Rock Capital Management LP 5.73 9,297,879 29.71 Stakes 2019-12-31
BlackRock Fund Advisors 4.00 6,497,851 20.76 13F 2020-03-31
State Street Corp. 3.94 6,398,385 20.44 13F 2020-03-31
BlackRock Institutional Trust Co. NA 3.22 5,225,541 16.70 13F 2020-03-31
Ecor1 Capital LLC 2.31 3,750,000 11.98 13F 2020-03-31
Ownership data is sourced through FactSet.

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