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Avacta: Avacta (AVCT:LN) develops next-generation biologics using its proprietary Affimer® platform technology. This technology is based on a naturally occurring human protein, engineered to behave like an antibody, but smaller, simpler, more robust, easy to format, cheaper and quicker to produce, highly specific to the target and non-immunogenic. In February 2019, Moderna exercised option on taking Affimer candidate(s) into clinical development.

-Lead assets are PD-L1/LAG-3 single molecule bispecific inhibitor and a PD-L1 tumour microenvironment targeted innate immune activators (I-DASH inhibitors, STING agonists)
-First-in-man clinical data expected in 2020.
-Partnerships with Moderna and OncoSec (Gene delivery), Memorial Sloan Kettering (CAR-T), Iksuda and Tufts University Medical School (Drug conjugates)
-Affimer reagents business for diagnostics and research

Near term newsflow:
-Candidate selection for anti-PD-L1/LAG-3 bispecific Affimer clinical proprietary development – (June 2019)
-Remains on track to submit an IND/CTA application by the end of 2020
-Completion of IND enabling studies for anti-PD-L1/LAG-3 bispecific - 2020
-Affimer therapeutics and reagents/diagnostics licensing
Based in...
Clinical Stage
Pre-Clinical Stage
Disease Space
Europe, Public
Market Cap
Therapeutic Modalities
Platform Technology
Unit 20, Ash Way
Thorp Arch Estate
Wetherby, York LS23 7FA
United Kingdom

Company Participants at European Biotech Investor Day 2019

  • Dr. Alastair Smith, Co-Founder and CEO

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Top 10 Holders of Avacta Group plc

Institution OS (%) Position Mkt Val ($MM) Source Filing Date
Miton Asset Management Ltd. 14.55 16,900,813 28.49 Stakes 2020-05-06
Baillie Gifford & Co. 10.10 11,734,089 19.78 Stakes 2020-06-10
Lombard Odier Asset Management (Europe) Ltd. 8.59 9,979,863 16.82 Stakes 2020-05-06
J.O. Hambro Capital Management Ltd. 7.43 8,625,000 14.54 Stakes 2020-04-21
Hargreaves Lansdown Stockbrokers Ltd. 7.08 8,226,000 13.87 Stakes 2020-04-02
Jarvis Investment Management Ltd. 5.85 6,791,000 11.45 Stakes 2020-04-02
FIL Investment Advisors (UK) Ltd. 5.81 6,754,122 11.38 Stakes 2020-01-02
Unicorn Asset Management Ltd. 5.17 6,000,000 10.11 Stakes 2020-04-24
Ruffer LLP 4.67 5,426,087 9.15 Stakes 2020-04-02
Hargreaves Lansdown Asset Management Ltd. 4.44 5,154,000 8.69 Stakes 2020-04-02
Ownership data is sourced through FactSet.

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