All Companies

Acceleron Pharma Inc [XLRN] $10,932 MM MCap
In pul­mo­nary, Ac­celeron is de­vel­op­ing so­tater­cept for the treat­ment of pul­mo­nary hy­per­ten­sion, cur­rent­ly in Phase 3 de­vel­op­ment, as well as ACE-1334 in SSc-ILD, which will be in the clin­ic by year-end. [more in­for­ma­tion]
AcelRx Pharmaceuticals, Inc. [ACRX] $62 MM MCap
Launched DSU­VIA (sufen­tanil sublin­gual tablet 30 mcg) in the US in 2019 for acute pain se­vere enough to re­quire opi­oid anal­gesic (adult pa­tients in cer­ti­fied med­i­cal­ly su­per­vised health­care sett­ings). Al­so de­vel­op­ing Za­lvi­so (Ph 3 com­plet­ed) in the US as an in­no­va­tive pa­tient-con­trolled anal­ge­sia sys­tem for mod­er­ate-to-se­vere acute pain in med­i­cal­ly su­per­vised sett­ings. [more in­for­ma­tion]
Affibody
Pro­pri­e­tary Af­fi­body® molecules and Al­bu­mod® plat­forms. Lead can­di­date ABY-035 is an IL-17 with mul­ti­ple Ph 2 pro­grams (PSO OLE PsA, axS­pA, uvei­tis). Pos­i­tive Ph2 52wk da­ta in pso­ri­a­sis with 2-yr OLE da­ta ex­pect­ed in 2H21. Ph2 in­ter­im da­ta for uvei­tis ex­pect­ed in 2022. AB-251 is a di­ag­nos­tic imag­ing pro­gram that is di­rect­ed pri­mar­i­ly to­wards me­tastat­ic breast can­cer. $81M raised to date. [more in­for­ma­tion]
Affimed N.V. [AFMD] $532 MM MCap
NK cell en­gager AFM13 (CD30/CD16A) en­rolling in a Phase 2 reg­is­tra­tion study in CD30-pos­i­tive pe­ripher­al T cell lym­pho­ma and an in­vesti­ga­tor-spon­sored study by MDACC of AFM13 com­bined with al­lo­gene­ic NK cells in re­lapsed/re­frac­to­ry CD30-pos­i­tive lym­pho­ma. [more in­for­ma­tion]
Aileron Therapeutics, Inc. [ALRN] $44 MM MCap
Clin­i­cal stage on­col­o­gy com­pany con­duct­ing 3 clin­i­cal trials for its lead can­di­date, AL­RN-6924, a first-in-class/best-in-class drug that tar­gets the p53 path­way. AL­RN-6924 is from the Sta­pled pep­tide plat­form and is the on­ly clin­i­cal drug can­di­date that binds equipo­tent­ly to both of the p53 sup­pres­sor pro­teins, MD­MX and MD­M2. [more in­for­ma­tion]
Alladapt Immunotherapeutics, Inc.
De­vel­op­ing a po­ten­tial­ly best-in-class oral im­munother­a­py that ad­dress­es a broad range of food al­ler­gies. AD­P101, which is cur­rent­ly in a Ph 1/2 clin­i­cal trial, is de­signed to de­sen­si­tize pa­tients al­ler­g­ic to one or to mul­ti­ple foods si­mul­ta­ne­ous­ly to miti­gate the risk of se­vere, life-threat­en­ing al­ler­g­ic re­ac­tions. The Com­pany was co-found­ed by Dr. Kari Nadeau, a renowned food al­ler­gist, and former 23andMe ex­ec, Ash­ley Dom­bkows­ki who serves as Al­la­dapt’s CEO. To date, the com­pany has raised $63 mil­lion. [more in­for­ma­tion]
Amarin Corporation [AMRN] $1,393 MM MCap
Com­mer­cial­iz­ing Vas­ce­pa, the first and on­ly pure EPA ome­ga-3 fat­ty acid ap­proved to low­er trig­lyc­eride lev­els in adults. Pre­sent­ed (+) da­ta from RE­DUCE-IT CV Out­comes trial at AHA. First 9mo rev’s of 2020 ~$450M. [more in­for­ma­tion]
Antev
Phase 3 ready, Tevere­lix, a long act­ing in­jectable pep­tide GnRH an­ta­g­on­ist. Lead in­di­ca­tion for pros­tate can­cer, fol­lowed by be­nign pro­stat­ic hy­per­pla­sia (BPH), acute uri­nary re­ten­tion (AUR), uterine fi­broids and en­dometrio­sis. Over 450 sub­jects have been dosed over 850 times to date with no se­ri­ous ad­verse re­ac­tions and good lo­cal tol­er­ance. [more in­for­ma­tion]
Aptorum Group [APM] $47 MM MCap
Hong Kong based, US list­ed com­pany fo­cused on gen­er­at­ing late stage clin­i­cal can­di­dates by de­vel­op­ing al­ready ap­proved drugs for new or­phan in­di­ca­tions, as well as in­fec­tious dis­eas­es. [more in­for­ma­tion]
Arbor Biotechnologies
An ear­ly-stage life sci­ences com­pany pi­oneer­ing the next-gen­er­a­tion of ge­net­ic medicines. With the most ex­ten­sive li­brary of CRIS­PR nu­cleas­es in the in­dus­try, a deep bench of world-class foun­ders (in­clud­ing gene edit­ing pi­oneer Feng Zhang) and sci­en­tif­ic ad­vi­sors, and a lead­er­ship team with a proven track re­cord of de­vel­op­ing nov­el plat­forms and ther­a­peu­tics, Ar­bor is well-po­si­tioned to de­vel­op cu­ra­tive ge­net­ic medicines for all pa­tients with ge­net­ic dis­eas­es. [more in­for­ma­tion]
Arcellx
On­go­ing Ph1 of po­ten­tial best-in-class BC­MA CAR-T. Clin­i­cal stage de­vel­op­ment of Anti­gen Re­cep­tor Com­plex T-cells (ARC-T) that are read­i­ly si­lenced, ac­ti­vat­ed and re­pro­grammed in vi­vo by ad­min­is­tra­tion of a tu­mor-tar­get­ing anti­gen pro­tein called a sparX. Backed by NEA, No­vo, SR One, Take­da, So­las­ta,&nb­sp;Quan, Clough, Mi­rae, JVC and LG.&nb­sp; [more in­for­ma­tion]
Arrivent
[more in­for­ma­tion]
AsclepiX Therapeutics
Oph­thal­mol­o­gy com­pany us­ing com­pu­ta­tio­n­al bi­ol­o­gy to iden­ti­fy po­tent pep­tide reg­u­la­tors of vas­cu­lar home­os­ta­sis. The lead clin­i­cal can­di­date, in­te­grin reg­u­lat­ing pep­tide AX­T107 (ger­sizan­gi­tide), has a nov­el mech­anism of ac­tion that in­hibits neo­vas­cu­lariza­tion, re­duces vas­cu­lar perme­a­bil­i­ty and sup­press­es in­flam­ma­tion. In June 2020, Per­cep­tive Xon­toge­ny Ven­ture Fund led the $35 mil­lion Se­ries A fi­nanc­ing with par­ti­ci­pa­tion from ex­ist­ing in­ves­tors Rapha Cap­i­tal Ma­n­age­ment and Bar­er & Son Cap­i­tal. [more in­for­ma­tion]
Assembly Biosciences, Inc. [ASMB] $93 MM MCap
A pi­oneer in the de­vel­op­ment of a new class of po­tent, oral core in­hibi­tor drug can­di­dates, As­sem­b­ly Bio’s ap­proach aims to break the com­plex vi­ral re­pli­ca­tion cy­cle of HBV to free pa­tients from a life­time of ther­a­py. As­sem­b­ly Bio’s strat­e­gy to­ward cure in­cludes a lead­ing port­fo­lio of more po­tent, next-gen­er­a­tion core in­hibi­tors, proof-of-con­cept com­bi­na­tion studies and a re­search pro­gram fo­cused on the dis­cov­ery of nov­el HBV tar­gets, in­clud­ing cc­cD­NA dis­rup­tors and two other undis­closed mech­anisms. In 202 [more in­for­ma­tion]
Austhera Biosciences
Un­lock­ing the FULL promise of poor­ly ab­sorbed drugs and cre­at­ing nov­el NCEs for on­col­o­gy and rare dis­ease, de­liv­er­ing op­ti­mal ther­a­peu­tic ben­e­fit to pa­tients by max­i­miz­ing drug ex­po­sure. Aus­thera al­so has full rights to use Dis­per­Sol’s Kineti­Sol tech­nol­o­gy plat­form in drug dis­cov­ery to find and de­vel­op in­sol­u­ble new chem­i­cal en­ti­ties (NCEs) of sig­ni­f­i­cant ther­a­peu­tic promise. [more in­for­ma­tion]
AxoGen [AXGN] $380 MM MCap
Glob­al lead­er in de­vel­op­ment and mar­ket­ing of in­no­va­tive sur­g­i­cal so­lu­tions for the pe­ripher­al nerve in­jury mar­ket. Gui­dance for 2021 rev­enue is $127M-$129M with ex­pect­ed 2021 Gross Mar­gin re­main­ing above 80%. Lead prod­uct Avance Nerve Graft is a pro­cessed, hu­man al­lo­graft for bridg­ing nerve gaps of up to 70 mm. [more in­for­ma­tion]
Bavarian Nordic A/S [BVNRY] $2,541 MM MCap
Vaccines for in­fec­tious dis­eas­es and on­col­o­gy. [more in­for­ma­tion]
Be Biopharma
Be Bio­phar­ma is a lead­er in de­vel­op­ing B cells as medicines, treat­ing dis­ease with the hu­man body’s na­tive pro­tein fac­to­ries. We pre­cise­ly en­gi­neer B cells to har­ness their in­trin­sic drug-like prop­er­ties – re­mark­able pro­tein pro­duc­tion, se­lec­tive tis­sue tar­get­ing, and fine con­trol of their cel­lu­lar en­vi­ron­ment – to forge a new cat­e­go­ry of cell ther­a­py. Be Bio was found­ed in Oc­to­ber 2020 by Long­wood Fund with a $52 mil­lion Se­ries A in­vest­ment led by At­las Ven­tures and RA Cap­i­tal, joined by Al­ta Part­n­ers and [more in­for­ma­tion]
Bellicum Pharmaceuticals Inc. [BLCM] $12 MM MCap
Molec­u­lar switch tech­nol­o­gy and co-stim do­mains en­ables phar­ma­co­log­ic con­trol over cells for en­hanced ef­fi­ca­cy and safe­ty. Lead (reg­is­tra­tio­n­al EU) pro­gram: Ph2 for ri­vo-cel (al­pha/be­ta ad­d­back T-cell ther­a­py for post al­lo­gene­ic HSTC in non-ma­lig­nant and ma­lig­nant dis­eas­es). Pos­i­tive late in­ter­im anal­y­sis on ri­vo-cel exp at ASH 2018; [more in­for­ma­tion]
Bellus Health [BLU] $670 MM MCap
BEL­LUS Health is de­vel­op­ing nov­el ther­a­peu­tics for the treat­ment of chron­ic cough and other hy­persen­si­ti­za­tion-re­lat­ed di­s­or­ders. BEL­LUS' lead prod­uct can­di­date, BLU-5937, is be­ing de­vel­oped for the treat­ment of chron­ic cough (Phase IIb SOOTHE pre-planned in­ter­im in Sept. 2021; to­p­line read­out in 4Q21) and chron­ic pru­ri­tus (Phase II BLUEPRINT read­out 4Q21). [more in­for­ma­tion]
Biohaven Pharmaceuticals, Inc [BHVN] $8,002 MM MCap
Com­mer­cial-stage, fo­cused on neu­ro­log­i­cal & neu­ropsychi­a­tric dis­eas­es; CGRP re­cep­tor an­ta­g­on­ist, glu­ta­mate mo­d­u­la­tion, and MPO plat­forms. NURTEC® ODT ap­proved 1Q20 acute treat­ment of mi­graine and 1Q21 pre­ven­tive treat­ment of mi­graine; $136m 3Q21 rev­enues. [more in­for­ma­tion]
CASI Pharmaceuticals Inc. [CASI] $101 MM MCap
Launched EVOMELA® (mel­pha­lan for in­jec­tion, mul­ti­ple myelo­ma) in Au­gust '19, on­ly mel­pha­lan com­mer­cial­ly avai­l­able in Chi­na: $7.1M 2Q21 rev­enues/guid­ing FY 2020 of over 80% growth. Co-com­mer­cial as­set CNCT-19/CD19 CAR-T (part­nered w/ Ju­ven­tas): on­go­ing Ph 2 trials in B-NHL and B-ALL. Dosed 1st pa­tient in Ph 1 study for CID-103 (an­ti-CD38 mAb) in EU in June 2021. [more in­for­ma­tion]
Celularity [CELU] $511 MM MCap
Celu­lar­i­ty, head­quar­tered in Florham Park, NJ, is a clin­i­cal-stage biotech­nol­o­gy com­pany fo­cus­ing on cel­lu­lar medicine by de­vel­op­ing off-the-shelf pla­cen­tal-de­rived al­lo­gene­ic cell ther­a­pies. Celu­lar­i­ty has a her­i­tage as a former cell-ther­a­py busi­ness unit of Cel­gene. [more in­for­ma­tion]
Clerio Vision, Inc.
Nov­el oph­thalmic tech­nol­o­gy to treat re­frac­tive er­ror ad­dress­ing mul­ti-bil­lion mar­kets in con­tact lens­es (pres­by­opia, astig­ma­tism, my­opia, my­opia pro­gres­sion) and corneal vi­sion cor­rec­tion (non sur­g­i­cal fla­p­less las­er so­lu­tion). Om­ni­fo­cal con­tact lens pres­by­opia 510k sub­mis­sion and my­opia pro­gres­sion clin­i­cal da­ta in 2H2022. Based on No­bel Prize win­n­ing fem­to-se­cond las­er tech­nol­o­gy de­vel­oped by Bausch & Lomb and the Uni­ver­si­ty of Roch­ester. [more in­for­ma­tion]
CureVac AG [CVAC] $4,577 MM MCap
Ger­man mR­NA com­pany with a di­ver­si­fied pipe­line; Ph 2a trial on­go­ing with COVID-19 vaccine can­di­date, CVn­CoV. Glob­al Ph 2/3 trial en­rolling ap­prox. 36,500 par­ti­ci­pants with re­sults ex­pect­ed 1Q21. Three other pro­grams in Ph 1: CV8102 (cu­ta­neous me­lano­ma, ade­noid­cys­tic car­ci­no­ma, squa­mous cell can­cer of skin, head & neck), CV9202 (NS­CLC) and CV7202 (Ra­bies). mR­NA-based anti­body de­liv­ery deal with Genmab (Dec'19). Other strate­g­ic part­n­er­ships in­clude GSK and CRIS­PR Tx. [more in­for­ma­tion]
DURECT Corporation [DRRX] $171 MM MCap
Fo­cused on ad­vanc­ing nov­el and po­ten­tial­ly life­sav­ing in­vesti­ga­tio­n­al ther­a­pies de­rived from its Epi­ge­net­ic Reg­u­la­tor Pro­gram. Lead com­pound, DUR-928, has been grant­ed FDA Fast Track Desig­na­tion for al­co­hol-as­so­ci­at­ed he­p­ati­tis (AH) and is be­ing eval­u­at­ed in NASH with pos­i­tive to­p­line Ph 1b da­ta. [more in­for­ma­tion]
ESSA Pharma Inc. [EPIX] $270 MM MCap
Fo­cused on de­vel­op­ing nov­el ther­a­pies for the treat­ment of pros­tate can­cer. ES­SA’s lead clin­i­cal can­di­date, EPI-7386 is an in­vesti­ga­tio­n­al, high­ly-se­lec­tive, oral, small molecule in­hibi­tor of the N-ter­mi­nal do­main of the an­dro­gen re­cep­tor, with Ph 1 monother­a­py da­ta ex­pect­ed in 1H 2022. The com­pany has al­so estab­lished clin­i­cal col­lab­o­ra­tions with JNJ, Astel­las, and Bay­er. [more in­for­ma­tion]
Galera Therapeutics [GRTX] $91 MM MCap
Clin­i­cal stage bio­phar­ma­ceu­ti­cal com­pany fo­cus­ing on trans­form­ing ra­dio­ther­a­py in can­cer. Fi­nal da­ta with 1 year+ fol­low up on all pa­tients for GC4419 in pan­cre­at­ic can­cer an­nounced in 3Q21. To­p­line da­ta from GC4711 in NS­CLC ex­pect­ed in 1H22. To­p­line da­ta from GC4711 in NS­CLC ex­pect­ed in 1H22. [more in­for­ma­tion]
GENFIT SA [GNFT] $245 MM MCap
Ipsen li­censed lead can­di­date EL­A­TIVE (ela­fi­branor) for &eu­ro;120M up­front pay­ment, up to &eu­ro;360M in po­ten­tial mile­s­tones, and dou­ble-dig­it roy­al­ties (tiered up to 20%). See Phase 3 EL­A­TIVE en­roll­ment com­ple­tion in 1Q22 and Phase 1 clin­i­cal da­ta for ni­ta­zox­anide (acute chron­ic liv­er fail­ure) by 3Q22 [more in­for­ma­tion]
Hangzhou Chance Pharmaceuticals
Chance fo­cus­es on in­ha­la­tion prod­ucts with pro­pri­e­tary tech­nolo­gies. [more in­for­ma­tion]
Heidelberg Pharma AG [HPHA:DB] €167 MM MCap
AT­AC plat­form to de­vel­op nov­el can­cer treat­ments with a unique mode of ac­tion killing both in­ac­tive and di­vid­ing can­cers cells and over­com­ing tu­mor re­sis­tance mech­anisms. Lead prod­uct HDP-101, for blood can­cer, is ex­pect­ed to start clin­i­cal dev' end of 2021. Out-li­cens­ing the AT­AC tech­nol­o­gy us­ing the part­n­ers’ anti­bodies to cre­ate new AT­ACs and ex­pect long term in­come streams and ear­ly tech­nol­o­gy vali­da­tion. [more in­for­ma­tion]
Hutchison China MediTech Ltd ("Chi-Med") [HCM] $5,372 MM MCap
Chi-Med has a port­fo­lio of 8 drugs in clin­i­cal de­vel­op­ment from own dis­cov­ery en­gine in its In­no­va­tion plat­form and a cash gen­er­at­ing Com­mer­cial plat­form with 2,500+ sales reps. Glob­al col­lab­o­ra­tion with As­traZene­ca in two reg­is­tra­tion en­abling studies with savol­i­tinib in Ta­gris­so re­frac­to­ry lung can­cer that is MET+ and EGFRm+ (glob­al) and MET Ex­on 14 dele­tion NS­CLC (Chi­na). [more in­for­ma­tion]
Impact Therapeutics Inc
IM­PACT and Jun­shi Bio­s­ciences estab­lished a 50:50 joint ven­ture that fo­cus­es on the de­vel­op­ment and com­mer­cial­iza­tion of Se­na­parib in Chi­na. The JV is cur­rent­ly con­duct­ing a Phase II piv­o­tal study and a Phase III study of Se­na­parib in ovarian can­cer third-line treat­ment and first-line main­te­nance treat­ment in Chi­na. [more in­for­ma­tion]
IN8bio, Inc. [INAB] $76 MM MCap
First com­pany to ad­vance ge­net­i­cal­ly-mod­i­fied gam­ma-del­ta T cells in­to clin­i­cal trials with its Del­tEx Plat­form, based on ex-vi­vo ex­pand­ed and ac­ti­vat­ed gam­ma-del­ta T cells. Two in­vesti­ga­tor-ini­ti­at­ed Phase 1 clin­i­cal trials are un­der­way for lead prod­uct can­di­dates: INB-200 for new­ly di­ag­nosed glioblas­to­ma and INB-100 for acute leukemia. [more in­for­ma­tion]
Iovance Biotherapeutics [IOVA] $2,430 MM MCap
De­vel­op­ing nov­el can­cer im­munother­a­pies based on tu­mor in­fil­trat­ing lym­pho­cytes (TIL) for the treat­ment of solid tu­mors. TIL ther­a­py is a high­ly per­so­n­al­ized ap­proach in which pa­tients re­ceive a one-time treat­ment with their own ex­pand­ed and re­ju­ve­nat­ed T-cells to treat can­cer. BLA ex­pect­ed in 1H22 fol­low­ing com­ple­tion of piv­o­tal study of Li­fileu­cel/LN-144 for treat­ment of Me­lano­ma. [more in­for­ma­tion]
Junshi Biosciences [1877.HK]
Has a di­ver­si­fied R&D pipe­line com­pris­ing over 21 drug can­di­dates with ther­a­peu­tic ar­eas cov­er­ing can­cer, metabolic, au­toim­mune, neu­ro­log­i­cal, and in­fec­tious dis­eas­es. Lead can­di­date, Tori­pal­imab (JS001), reached over 1B RMB in sales, and ex­pand­ed in­di­ca­tions in­to na­sopha­ryn­geal car­ci­no­ma/urothe­lial car­ci­no­ma. Other prod­uct types in­clude mon­o­clo­n­al anti­bodies, fu­sion pro­teins, anti­body-drug con­ju­gates, and small molecule drugs. With a com­bined 33,000L fer­men­ta­tion ca­pac­i­ty in two GMP-fa­cil­i­ties at Shang­hai [more in­for­ma­tion]
Keros Therapeutics [KROS] $1,212 MM MCap
A lead­er in un­der­s­tand­ing the role of the TGF-Be­ta fam­i­ly of pro­teins that is a mas­ter reg­u­la­tor of RBC and platelet pro­duc­tion as well as the growth, re­pair and main­te­nance of mus­cle and bone. Lead pro­tein ther­a­peu­tic prod­uct can­di­date, KER-050, is be­ing de­vel­oped for the treat­ment of cy­tope­nias, in­clud­ing ane­mia and throm­bo­cy­tope­nia, in pa­tients with myelodys­plas­tic syn­drome (MDS) and myelo­fi­bro­sis, with ad­di­tio­n­al da­ta ex­pect­ed from Part 1 of Ph 2 study in MDS be­ing pre­sent­ed at ASH 2021. [more in­for­ma­tion]
Kintor Pharma [9939.HK]
Two Ph3s on­go­ing in Chi­na: Piv­o­tal monother­a­py and com­bo with abi­raterone and a Ph2 on­go­ing in US for mCR­PC (with breast and other AR-driv­en can­cers be­hind). Ad­di­tio­n­al pipe­line in­cludes a top­i­cal AR for alope­cia and ear­li­er-stage tar­gets in­clud­ing ALK-1 and hedge­hog. [more in­for­ma­tion]
Lineage Cell Therapeutics Inc. [LCTX] $283 MM MCap
Cell ther­a­py com­pany with 3 clin­i­cal pro­grams 1) OpRe­gen, an RPE tran­s­plant ther­a­py in Ph1/2a de­vel­op­ment for the treat­ment of dry-AMD. 2) OPC1, an oli­go­den­dro­cyte pro­gen­i­tor cell ther­a­py for acute spi­nal cord in­juries with Or­phan and RMAT desig­na­tions. 3) VAC2, an al­lo­gene­ic can­cer im­munother­a­py of anti­gen-pre­sent­ing den­drit­ic cells cur­rent­ly in a Ph 1 for NS­CLC con­duct­ed by CRUK. [more in­for­ma­tion]
Marker Therapeutics [MRKR] $67 MM MCap
Fo­cused on de­vel­op­ing next-gen­er­a­tion T cell-based im­munother­a­pies for the treat­ment of he­ma­to­log­i­cal ma­lig­nan­cies and solid tu­mor in­di­ca­tions. Mark­er's cell ther­a­py tech­nol­o­gy is based on the se­lec­tive ex­pan­sion of non-en­gi­neered, tu­mor-spe­cif­ic T cells that rec­og­nize tu­mor as­so­ci­at­ed anti­gens and kill tu­mor cells ex­press­ing those tar­gets. [more in­for­ma­tion]
MiNA Therapeutics
Ver­satile, pro­pri­e­tary small ac­ti­vat­ing ri­bonu­cle­ic acid (saR­NA) ther­a­peu­tics plat­form and in­ter­nal pipe­line, ini­tial­ly fo­cus­ing on on­col­o­gy and rare dis­ease in­di­ca­tions. Ini­ti­at­ing ran­domized Ph2 study for lead saR­NA drug can­di­date MTL-CEB­PA com­bined with so­rafenib in 2L HCC in 1Q22. Ph1b read­out in solid tu­mors (MTL-CEB­PA+Pem­bro PD-1) in 1Q22. $1.5B+ phar­ma part­n­er­ships. [more in­for­ma­tion]
Monte Rosa Therapeutics [GLUE] $698 MM MCap
Next-gen­er­a­tion molec­u­lar glue-based tar­get­ed pro­tein degra­da­tion plat­form de­vel­op­ing small molecule ther­a­peu­tics that se­lec­tive­ly de­grade dis­ease-caus­ing pro­teins. Tar­get­ing the un­drug­gable pro­teome in on­col­o­gy and non-on­col­o­gy in­di­ca­tions via AI based de­gron pre­dic­tion. Lead pro­gram fo­cused on GSP­T1, a key reg­u­la­tor and vul­n­er­a­bil­i­ty of Myc-in­duced trans­la­tio­n­al ad­dic­tion. [more in­for­ma­tion]
Neogene Therapeutics
Neo­gene’s nov­el ap­proach in­tends to de­liv­er a tailored set of TCR genes for each in­di­vi­d­u­al pa­tient, which will be en­gi­neered in­to pa­tient-de­rived T cells di­rect­ing them to­ward neo-anti­gens in tu­mor cells, with the goal of pro­vid­ing a ful­ly in­di­vi­d­u­al­ized en­gi­neered T cell ther­a­py for can­cer. The Com­pany raised a $110M Se­ries A fi­nanc­ing co-led by EcoR1 Cap­i­tal, Jei­to Cap­i­tal and Syn­co­na, with par­ti­ci­pa­tion from Po­laris Part­n­ers, Pon­ti­fax, Seed in­ves­tors, Vi­da Ven­tures, TPG and Two Riv­er. [more in­for­ma­tion]
Neoleukin Therapeutics [NLTX] $162 MM MCap
Its lead prod­uct can­di­date, NL-201, is a com­bined IL-2 and IL-15 ag­on­ist de­signed to im­prove tol­er­a­bil­i­ty and ac­tiv­i­ty by elim­i­nat­ing the al­pha re­cep­tor bind­ing in­ter­face. NL-201 is cur­rent­ly be­ing eval­u­at­ed in a Phase 1 clin­i­cal trial in pa­tients with re­lapsed or re­frac­to­ry can­cer and the com­pany is ex­pect­ing in­ter­im da­ta in 2022. [more in­for­ma­tion]
NexImmune, Inc. [NEXI] $84 MM MCap
Mul­ti-anti­gen-spe­cif­ic T cell ther­a­py. Syn­thet­ic nano­par­ti­cles de­c­o­rat­ed w a com­bo of mul­ti­ple tu­mor rel­e­vant anti­gens and co-sti­m­u­la­to­ry sig­nals en­gag­ing di­rect­ly w tar­get­ed T cells. Two Ph 1's on­go­ing. [more in­for­ma­tion]
NorthSea Therapeutics
Fo­cused on de­vel­op­ing SE­FAs for the treat­ment of NASH and other metabolic di­s­or­ders. Lead prod­uct, icos­abu­tate has been found safe and ef­fec­tive in two pri­or phase 2 clin­i­cal studies for treat­ment of hy­per­trig­lyc­eridemia and mixed dys­lipi­demia and is cur­rent­ly in clin­i­cal de­vel­op­ment for NASH. The icos­abu­tate phase 2b ICO­NA NASH trial is sche­d­uled to read­out in the first quar­ter of 2023. Two ad­di­tio­n­al SE­FAs are in clin­i­cal de­vel­op­ment; SE­FA 1024 is in phase 1 to be de­vel­oped for dys­lipi­demia and SE­FA 6179, [more in­for­ma­tion]
Novavax AB [NVAX] $8,379 MM MCap
Clin­i­cal-stage vaccine com­pany lev­er­ag­ing re­com­bi­nant nano­par­ti­cle tech­nol­o­gy plat­form to ad­dress a broad range of in­fec­tious dis­eas­es. NVX-CoV­2373, lead vaccine can­di­date against SARS-CoV-2 is be­ing eval­u­at­ed in two piv­o­tal Ph 3 trials [more in­for­ma­tion]
Nykode Therapeutics [NYKD:OL]
Ap­prox­i­mate $2.5B mar­ket cap, clin­i­cal stage im­munother­a­py com­pany fo­cused on can­cer and in­fec­tious dis­ease. Mo­d­u­lar vaccine tech­nol­o­gy tar­gets anti­gens to Anti­gen Pre­sent­ing Cells to achieve rapid, strong and long-last­ing im­mune re­spons­es. Key pro­grams in­clude Ph2 pro­pri­e­tary HPV 16+ cer­vi­cal can­cer ther­a­peu­tic vaccine, Ph2 in­di­vi­d­u­al­ized can­cer neoanti­gen vaccine (Ge­nen­tech), Ph1/2 next-gen­er­a­tion COVID-19 T-cell vaccines. Sig­ni­f­i­cant col­lab­o­ra­tions with Re­generon, Ge­nen­tech, Adap­tive Biotech­nolo­gies. [more in­for­ma­tion]
OnKure Therapeutics, Inc.
De­vel­op­ing epi­ge­net­ic can­cer ther­a­pies in­clud­ing HDAC in­hibi­tors. Lead as­set OKI-179 is a class 1 HDAC in­hibi­tor in Ph 1. [more in­for­ma­tion]
Photocure ASA [PHO:OS] NKr2,517 MM MCap
Rev­enue-gen­er­at­ing urol­o­gy-fo­cused com­pany. Lead prod­uct, Hexvix®/Cysview® im­proves de­tec­tion of blad­der can­cer un­der blue light cys­tos­copy (BLC), which can re­duce dis­ease re­cur­rence and pro­gres­sion rates. Hexvix®/Cysview® is in­clud­ed in clin­i­cal consen­sus guide­lines and re­mains on a strong growth path. Rev­enues in 2020 to­taled $31M. Re­cent­ly suc­cess­ful­ly launched the Eu­ro­pean Hexvix op­er­a­tions, con­soli­dat­ing the Com­pany’s prod­uct franchise glob­al­ly. [more in­for­ma­tion]
Savara Inc. [SVRA] $148 MM MCap
Clin­i­cal-stage bio­phar­ma fo­cused on rare re­s­pi­ra­to­ry dis­eas­es; mol­gra­mos­tim, an in­haled gran­u­lo­cyte-macrophage colony-sti­m­u­lat­ing fac­tor (GM-CSF), is in Phase 3 de­vel­op­ment for the treat­ment of au­toim­mune pul­mo­nary alve­o­lar pro­tei­no­sis (aPAP); top-line da­ta from the dou­ble-blind pe­ri­od of the Com­pany’s Phase 3 trial (IM­PALA 2) is an­ti­ci­pat­ed at the end of 2Q 2024. [more in­for­ma­tion]
Secarna Pharmaceuticals GmbH
Se­car­na's unique­ly ef­fi­cient LNA­plus™ dis­cov­ery pro­cess is fu­eled by their pro­pri­e­tary and stream­lined Oli­go­fy­er™ bioin­for­mat­ics sys­tems large in-house cell li­brary and own in vit­ro screen­ing as­says. [more in­for­ma­tion]
Sigilon Therapeutics, Inc. [SGTX] $71 MM MCap
En­gi­neer­ing cells to pro­duce miss­ing pro­teins/en­zymes/etc; en­cap­su­late cells in pro­pri­e­tary sphere ma­trix (dev’d at Bob Langer's Lab at MIT) to pre­vent fi­bro­sis & im­mune re­jec­tion; 2 can­di­dates in clin­ic by year-end 2021 (SIG-001 in Hem A & SIG-005 in MPS-1); Eli Lil­ly col­lab­o­ra­tion in T1D ($75m ini­tial com­mit­ment, $410 mile­s­tones & sin­gle to dou­ble dig­it roy­al­ties) [more in­for­ma­tion]
Sonnet Biotherapeutics, Inc. [SONN] $21 MM MCap
Uti­l­iz­ing a plat­form ap­proach to de­vel­op im­muno-on­col­o­gy ther­a­peu­tics fea­tur­ing a pro­pri­e­tary ful­ly hu­man Al­bu­min Bin­der ca­pa­ble of link­ing 1-2 dif­fer­ent ther­a­peu­tic tar­gets. Son­net's in­ter­leukin-based can­di­date has been shown to en­hance pK (up to 10 fold) and im­prove tu­mor de­liv­ery with an in­crease in in vi­vo ef­fi­ca­cy (30 fold) as de­mon­s­trat­ed in a mice tu­mor mod­el. [more in­for­ma­tion]
Spruce Biosciences [SPRB] $80 MM MCap
Fo­cused on de­vel­op­ing and com­mer­cial­iz­ing nov­el ther­a­pies for rare en­docrine di­s­or­ders. The com­pany’s lead prod­uct can­di­date, Til­dac­er­font, is cur­rent­ly be­ing eval­u­at­ed for the treat­ment of clas­sic adult con­geni­tal adre­nal hy­per­pla­sia (CAH), and in up­com­ing studies in pe­di­a­tric clas­sic CAH and Po­ly­cys­tic Ovary Syn­drome (PCOS). [more in­for­ma­tion]
Sutro Biopharma [STRO] $495 MM MCap
Fo­cused on de­vel­op­ing next gen­er­a­tion anti­body drug con­ju­gates (ADCs) and other com­plex bi­o­log­ics for can­cer. The com­pany’s FolR&al­pha;-tar­get­ing ADC (STRO-002) in ovarian can­cer is cur­rent­ly in Ph 1 with dose-ex­pan­sion da­ta ex­pect­ed in 2H 2021. En­roll­ment is on­go­ing for CD74-tar­get­ing ADC (STRO-001) in the Ph 1 dose-es­ca­la­tion in B-cell ma­lig­nan­cies. Sutro has three high val­ue col­lab­o­ra­tions with BMS, Mer­ck, and EMD Serono. [more in­for­ma­tion]
Treos Bio Limited
De­vel­ops pre­ci­sion pep­tide can­cer im­munother­a­pies us­ing pa­tient HLA tar­get recog­ni­tion ge­net­ics based on pro­pri­e­tary com­pu­ta­tio­n­al da­ta sci­ence. Tre­os’ lead can­di­date is Po­lyPEPI-1018, an off-the-shelf im­munother­a­py for the treat­ment of me­tastat­ic col­orec­tal can­cer cur­rent­ly in a bio­mark­er-based Phase 1b clin­i­cal trial. Tre­os has raised $42 mil­lion to date. [more in­for­ma­tion]
Tryp Therapeutics [TRYPF] $14 MM MCap
Tryp Ther­a­peu­tics Inc is a phar­ma­ceu­ti­cal com­pany fo­cused on iden­ti­fy­ing and de­vel­op­ing clin­i­cal-stage com­pounds for or­phan dis­eas­es and other dis­eas­es with high un­met med­i­cal needs. The com­pany's main de­vel­op­ment pro­gram PFN pro­gram, is de­signed to treat neu­ropsychi­a­tric di­s­or­ders through the dos­ing of for­mu­la­tions of syn­thet­ic psilo­cy­bin. [more in­for­ma­tion]
Verrica Pharmaceuticals [VRCA] $229 MM MCap
A der­ma­tol­o­gy ther­a­peu­tics com­pany de­vel­op­ing med­i­ca­tions for skin dis­eas­es re­quir­ing med­i­cal in­ter­ven­tions. Ver­ri­ca's lead prod­uct can­di­date, VP-102, is a GMP-con­trolled for­mu­la­tion of can­tharidin de­liv­ered via a sin­gle-use ap­pli­ca­tor for the treat­ment of mol­lus­cum con­ta­gio­sum (mol­lus­cum), com­mon warts and ex­ter­nal geni­tal warts. The Com­pany is al­so de­vel­op­ing treat­ments for plan­tar warts (VP-103) and basal cell car­ci­no­ma (LTX-315). [more in­for­ma­tion]
Vivoryon [VVY:AS] €333 MM MCap
Fo­cused on nov­el small molecule in­hibi­tors of glu­taminyl cy­clase (QPCT) de­signed to pre­vent the for­ma­tion of patho­log­i­cal­ly al­tered pro­teins be­fore they cause ir­re­v­ersi­ble da­m­age. Lead can­di­date varog­lu­tam­s­tat, cur­rent­ly in Phase 2 in Alzheimer’s dis­ease (AD), tar­gets all three ma­jor hall­marks of AD. [more in­for­ma­tion]
XOMA Corporation [XOMA] $252 MM MCap
Biotech roy­al­ty and mile­s­tone ag­gre­ga­tor with port­fo­lio of 70+ as­sets in >30 dis­closed in­di­ca­tions where R&D costs are borne by part­n­ers e.g. Roche's Faricimab (BLA filed for nAMD and DME 7/29/21) [more in­for­ma­tion]
Zentalis [ZNTL] $3,060 MM MCap
De­vel­op­ing best-in-class small molecule ther­a­peu­tics tar­get­ing fun­da­men­tal bi­o­log­i­cal can­cer path­ways. WEE1 in­hibi­tor for ad­vanced solid tu­mors cur­rent­ly in Ph 2. ZN-c5, an oral SERD for breast can­cer, ZN-d5, a BCL-2 in­hibi­tor for he­ma­to­log­ic ma­lig­nan­cies, and ZN-e4, an EGFR in­hibi­tor for NS­CLC. [more in­for­ma­tion]