All Companies

Abliva Ab [ABLI:ST] SKr210 MM MCap
Fo­cused on rare and se­vere pri­mary mi­to­chon­drial dis­eas­es (PMD). KL1333, a NAD+ reg­u­la­tor, to ac­cel­er­ate in­to piv­o­tal studies in 2H21 based on pos­i­tive FDA feed­back; ini­tial re­sults from Ph1b in PMD pa­tients exp. in 1Q21. NV354, an en­er­gy re­place­ment ther­a­py for Leigh Syn­drome, in IND-en­abling studies. [more in­for­ma­tion]
Acceleron Pharma Inc [XLRN] $10,569 MM MCap
In pul­mo­nary, Ac­celeron is de­vel­op­ing so­tater­cept for the treat­ment of pul­mo­nary hy­per­ten­sion, cur­rent­ly in Phase 3 de­vel­op­ment, as well as ACE-1334 in SSc-ILD, which will be in the clin­ic by year-end. [more in­for­ma­tion]
AcelRx Pharmaceuticals, Inc. [ACRX] $122 MM MCap
Launched DSU­VIA (sufen­tanil sublin­gual tablet 30 mcg) in the US in 2019 for acute pain se­vere enough to re­quire opi­oid anal­gesic (adult pa­tients in cer­ti­fied med­i­cal­ly su­per­vised health­care sett­ings). Al­so de­vel­op­ing Za­lvi­so (Ph 3 com­plet­ed) in the US as an in­no­va­tive pa­tient-con­trolled anal­ge­sia sys­tem for mod­er­ate-to-se­vere acute pain in med­i­cal­ly su­per­vised sett­ings. [more in­for­ma­tion]
Affibody
Pro­pri­e­tary Af­fi­body® molecules and Al­bu­mod plat­forms. Lead can­di­date is an IL-17 with pos­i­tive Ph2 52wk da­ta in pso­ri­a­sis and Ph2 IND for lead in­di­ca­tion uvei­tis will be filed in Q1 2021. In ad­di­tion, the com­pany has an on­go­ing re­la­tion­ship with In­ma­gene in Chi­na. Backed by In­ves­tor AB. [more in­for­ma­tion]
Affimed N.V. [AFMD] $708 MM MCap
NK cell en­gager AFM13 (CD30/CD16A) en­rolling in a Phase 2 reg­is­tra­tion study in CD30-pos­i­tive pe­ripher­al T cell lym­pho­ma and an in­vesti­ga­tor-spon­sored study by MDACC of AFM13 com­bined with al­lo­gene­ic NK cells in re­lapsed/re­frac­to­ry CD30-pos­i­tive lym­pho­ma. [more in­for­ma­tion]
Aileron Therapeutics, Inc. [ALRN] $91 MM MCap
Clin­i­cal stage on­col­o­gy com­pany con­duct­ing 3 clin­i­cal trials for its lead can­di­date, AL­RN-6924, a first-in-class/best-in-class drug that tar­gets the p53 path­way. AL­RN-6924 is from the Sta­pled pep­tide plat­form and is the on­ly clin­i­cal drug can­di­date that binds equipo­tent­ly to both of the p53 sup­pres­sor pro­teins, MD­MX and MD­M2. [more in­for­ma­tion]
Alladapt Immunotherapeutics, Inc.
Al­la­dapt is rei­magin­ing the treat­ment of food al­ler­gy, de­vel­op­ing a po­ten­tial­ly best-in-class oral im­munother­a­py that ad­dress­es a broad range of food al­ler­gies. AD­P101, which is cur­rent­ly in a Phase 1/2 clin­i­cal trial, is de­signed to de­sen­si­tize pa­tients al­ler­g­ic to one or to mul­ti­ple foods si­mul­ta­ne­ous­ly to miti­gate the risk of se­vere, life-threat­en­ing al­ler­g­ic re­ac­tions. [more in­for­ma­tion]
Amarin Corporation [AMRN] $2,040 MM MCap
Com­mer­cial­iz­ing Vas­ce­pa, the first and on­ly pure EPA ome­ga-3 fat­ty acid ap­proved to low­er trig­lyc­eride lev­els in adults. Pre­sent­ed (+) da­ta from RE­DUCE-IT CV Out­comes trial at AHA. First 9mo rev’s of 2020 ~$450M. [more in­for­ma­tion]
Antev
Phase 3 ready, Tevere­lix, a long act­ing in­jectable pep­tide GnRH an­ta­g­on­ist. Lead in­di­ca­tion for pros­tate can­cer, fol­lowed by be­nign pro­stat­ic hy­per­pla­sia (BPH), acute uri­nary re­ten­tion (AUR), uterine fi­broids and en­dometrio­sis. Over 450 sub­jects have been dosed over 850 times to date with no se­ri­ous ad­verse re­ac­tions and good lo­cal tol­er­ance. [more in­for­ma­tion]
Aptorum Group [APM] $92 MM MCap
Hong Kong based, US list­ed com­pany fo­cused on gen­er­at­ing late stage clin­i­cal can­di­dates by de­vel­op­ing al­ready ap­proved drugs for new or­phan in­di­ca­tions, as well as in­fec­tious dis­eas­es. [more in­for­ma­tion]
Arbor Biotechnologies
An ear­ly-stage life sci­ences com­pany pi­oneer­ing the next-gen­er­a­tion of ge­net­ic medicines. With the most ex­ten­sive li­brary of CRIS­PR nu­cleas­es in the in­dus­try, a deep bench of world-class foun­ders (in­clud­ing gene edit­ing pi­oneer Feng Zhang) and sci­en­tif­ic ad­vi­sors, and a lead­er­ship team with a proven track re­cord of de­vel­op­ing nov­el plat­forms and ther­a­peu­tics, Ar­bor is well-po­si­tioned to de­vel­op cu­ra­tive ge­net­ic medicines for all pa­tients with ge­net­ic dis­eas­es. [more in­for­ma­tion]
Arcellx
Clin­i­cal stage de­vel­op­ment of Anti­gen Re­cep­tor Com­plex T-cells (ARC-T) that are read­i­ly si­lenced, ac­ti­vat­ed and re­pro­grammed in vi­vo by ad­min­is­tra­tion of a tu­mor-tar­get­ing anti­gen pro­tein called a sparX. Backed by NEA, No­vo, SR One, Take­da, So­las­ta, Quan, Clough, Mi­rae, JVC and LG. [more in­for­ma­tion]
Arrivent
[more in­for­ma­tion]
AsclepiX Therapeutics
Lead com­pound AX­T107: nov­el pep­tide, in­hibit­ing VEGF and ac­ti­vat­ing Tie2 is the on­ly ther­a­peu­tic in clin­i­cal de­vel­op­ment for DME and wet AMD that was iden­ti­fied through a pro­cess of Ar­ti­fi­cial In­tel­li­gence, min­ing the hu­man pro­teome for cryp­tic an­ti an­gio­genic and home­o­stat­ic pep­tides, rather than through a stan­dard drug de­vel­op­ment pro­cess. [more in­for­ma­tion]
Assembly Biosciences, Inc. [ASMB] $147 MM MCap
Tar­get­ing HBV w/ oral core in­hibi­tors - po­ten­tial to in­crease cure rates. Lead can­di­date 731 in Ph 2: +ive safe­ty and de­creas­es in cc­cD­NA pop with pts ex­pect­ed to be with­drawn from treat­ment in 2020 and fol­lowed for sus­tained vi­ral DNA sup­pres­sion off ther­a­py. [more in­for­ma­tion]
Austhera Biosciences
Un­lock­ing the FULL promise of poor­ly ab­sorbed drugs and cre­at­ing nov­el NCEs for on­col­o­gy and rare dis­ease, de­liv­er­ing op­ti­mal ther­a­peu­tic ben­e­fit to pa­tients by max­i­miz­ing drug ex­po­sure. Aus­thera al­so has full rights to use Dis­per­Sol’s Kineti­Sol tech­nol­o­gy plat­form in drug dis­cov­ery to find and de­vel­op in­sol­u­ble new chem­i­cal en­ti­ties (NCEs) of sig­ni­f­i­cant ther­a­peu­tic promise. [more in­for­ma­tion]
AxoGen [AXGN] $564 MM MCap
Ax­o­gen (AXGN) is a glob­al lead­er in de­vel­op­ment/mar­ket­ing of sur­g­i­cal so­lu­tions for pe­ripher­al nerve mar­ket with 2021 rev­enue gui­dance of $134.5M-$137.5M. Lead prod­uct Avance Nerve Graft is a pro­cessed, hu­man al­lo­graft for bridg­ing nerve gaps of up to 70 mm. [more in­for­ma­tion]
Bavarian Nordic A/S [BVNRY] $2,876 MM MCap
Vaccines for in­fec­tious dis­eas­es and on­col­o­gy. [more in­for­ma­tion]
Bellicum Pharmaceuticals Inc. [BLCM] $22 MM MCap
Molec­u­lar switch tech­nol­o­gy and co-stim do­mains en­ables phar­ma­co­log­ic con­trol over cells for en­hanced ef­fi­ca­cy and safe­ty. Lead (reg­is­tra­tio­n­al EU) pro­gram: Ph2 for ri­vo-cel (al­pha/be­ta ad­d­back T-cell ther­a­py for post al­lo­gene­ic HSTC in non-ma­lig­nant and ma­lig­nant dis­eas­es). Pos­i­tive late in­ter­im anal­y­sis on ri­vo-cel exp at ASH 2018; [more in­for­ma­tion]
Bellus Health [BLU] $477 MM MCap
BEL­LUS Health is de­vel­op­ing nov­el ther­a­peu­tics for the treat­ment of chron­ic cough and other hy­persen­si­ti­za­tion-re­lat­ed di­s­or­ders. BEL­LUS' lead prod­uct can­di­date, BLU-5937, is be­ing de­vel­oped for the treat­ment of chron­ic cough (Phase IIb SOOTHE pre-planned in­ter­im in Sept. 2021; to­p­line read­out in 4Q21) and chron­ic pru­ri­tus (Phase II BLUEPRINT read­out 4Q21). [more in­for­ma­tion]
BerGenBio [BGBIO:OS] NKr1,777 MM MCap
De­vel­op­ing first-in-class se­lec­tive Axl ki­nase in­hibi­tors for liquid and solid can­cers, lead can­di­date is bem­cen­tinib (BG­B324) in four com­pany-spon­sored trials. [more in­for­ma­tion]
Biohaven Pharmaceuticals, Inc [BHVN] $8,738 MM MCap
NURTEC® ODT ap­proved in 1Q20. NURTEC® ODT for pre­ven­ta­tive treat­ment of mi­graine ap­proved 1Q2021. 4Q21 exp. Ph3 MSA read­out. [more in­for­ma­tion]
BiomX [PHGE] $69 MM MCap
The com­pany's ther­a­peu­tics dis­cov­er and vali­date pro­pri­e­tary bac­te­rial tar­gets, de­vel­op ra­tio­n­al­ly de­signed phage ther­a­pies that seek and de­stroy harm­ful bac­te­ria in mi­cro­biome-re­lat­ed dis­eas­es, en­abling med­i­cal prac­ti­tion­ers to erad­i­cate harm­ful bac­te­ria in chron­ic dis­eas­es. [more in­for­ma­tion]
CASI Pharmaceuticals Inc. [CASI] $161 MM MCap
Co-com­mer­cial as­set CNCT-19/CD19 CAR-T (part­nered w/ Ju­ven­tas): on­go­ing Ph 1 trials in B-NHL and B-ALL, exp to ini­ti­ate reg­is­tra­tion trials by YE 2020. Exp to ini­ti­ate Ph 1 study for CID-103 (an­ti-CD38 mAb) in EU in Q1 2021. [more in­for­ma­tion]
Celularity [CELU] $888 MM MCap
Celu­lar­i­ty, head­quar­tered in Florham Park, NJ, is a clin­i­cal-stage biotech­nol­o­gy com­pany fo­cus­ing on cel­lu­lar medicine by de­vel­op­ing off-the-shelf pla­cen­tal-de­rived al­lo­gene­ic cell ther­a­pies. Celu­lar­i­ty has a her­i­tage as a former cell-ther­a­py busi­ness unit of Cel­gene. [more in­for­ma­tion]
Clerio Vision, Inc.
Nov­el oph­thalmic tech­nol­o­gy to treat re­frac­tive er­ror ad­dress­ing mul­ti-bil­lion mar­kets in con­tact lens­es (pres­by­opia, astig­ma­tism, my­opia, my­opia pro­gres­sion) and corneal vi­sion cor­rec­tion (non sur­g­i­cal fla­p­less las­er so­lu­tion). Based on No­bel Prize win­n­ing fem­to-se­cond las­er tech­nol­o­gy de­vel­oped by Bausch & Lomb and the Uni­ver­si­ty of Roch­ester. [more in­for­ma­tion]
CureVac AG [CVAC] $7,440 MM MCap
Ger­man mR­NA com­pany with a di­ver­si­fied pipe­line; Ph 2a trial on­go­ing with COVID-19 vaccine can­di­date, CVn­CoV. Glob­al Ph 2/3 trial en­rolling ap­prox. 36,500 par­ti­ci­pants with re­sults ex­pect­ed 1Q21. Three other pro­grams in Ph 1: CV8102 (cu­ta­neous me­lano­ma, ade­noid­cys­tic car­ci­no­ma, squa­mous cell can­cer of skin, head & neck), CV9202 (NS­CLC) and CV7202 (Ra­bies). mR­NA-based anti­body de­liv­ery deal with Genmab (Dec'19). Other strate­g­ic part­n­er­ships in­clude GSK and CRIS­PR Tx. [more in­for­ma­tion]
DURECT Corporation [DRRX] $268 MM MCap
Our goal was to op­ti­mize the phys­i­cal, phar­ma­coki­net­ic, and phar­ma­co­dy­nam­ic prop­er­ties of ap­proved ac­tive agents in ways that would solve sig­ni­f­i­cant clin­i­cal problems. [more in­for­ma­tion]
ESSA Pharma Inc. [EPIX] $235 MM MCap
In Ph1b with a small molecule drug tar­get­ing the n-ter­mi­nal do­main of the an­dro­gen re­cep­tor. Po­ten­tial for treat­ment post-cur­rent AR ther­a­pies and in com­bi­na­tion in ear­li­er lines. Pfiz­er par­ti­ci­pat­ed in most re­cent fundrais­ing. Re­cent col­lab­o­ra­tions with Bay­er, Astel­las, and Janssen to eval­u­ate com­bi­na­tions with their main drug can­di­date EPI-7386. [more in­for­ma­tion]
Galera Therapeutics [GRTX] $206 MM MCap
Clin­i­cal stage bio­phar­ma­ceu­ti­cal com­pany fo­cus­ing on trans­form­ing ra­dio­ther­a­py in can­cer. Lead as­set ava­so­pasem is a po­tent, high­ly se­lec­tive small molecule dis­mu­tase mimet­ic be­ing de­vel­oped for se­vere oral mu­cosi­tis, cur­rent­ly in Phase 3 with Break­through Ther­a­py Desig­na­tion. To­p­line re­sults ex­pect­ed in 4Q21. [more in­for­ma­tion]
Genfit SA [GNFT] $168 MM MCap
De­vel­op­ment of po­ten­tial liv­er dis­ease treat­ment: ela­fi­branor in PBC: on­go­ing en­roll­ment for Ph 3 clin­i­cal trial EL­A­TIVE, fol­low-on PSC in­di­ca­tion. Com­mer­cial­iza­tion of NIS4™ for NASH di­ag­no­sis [more in­for­ma­tion]
Hangzhou Chance Pharmaceuticals
Chance fo­cus­es on in­ha­la­tion prod­ucts with pro­pri­e­tary tech­nolo­gies. [more in­for­ma­tion]
Heidelberg Pharma AG [HPHA:DB] €185 MM MCap
Hei­del­berg Phar­ma AG (HPHA, Frank­furt Stock Exchange), based in La­den­burg, Ger­many, is a lead­ing biotech com­pany pi­oneer­ing the use of its AT­AC (Anti­body Tar­get­ed Amanitin Con­ju­gate) plat­form to de­vel­op nov­el can­cer treat­ments with a unique mode of ac­tion ef­fec­tive at spe­cif­i­cal­ly killing both in­ac­tive and di­vid­ing can­cers cells and over­com­ing tu­mor re­sis­tance mech­anisms. [more in­for­ma­tion]
Hutchison China MediTech Ltd ("Chi-Med") [HCM] $5,584 MM MCap
Chi-Med has a port­fo­lio of 8 drugs in clin­i­cal de­vel­op­ment from own dis­cov­ery en­gine in its In­no­va­tion plat­form and a cash gen­er­at­ing Com­mer­cial plat­form with 2,500+ sales reps. Glob­al col­lab­o­ra­tion with As­traZene­ca in two reg­is­tra­tion en­abling studies with savol­i­tinib in Ta­gris­so re­frac­to­ry lung can­cer that is MET+ and EGFRm+ (glob­al) and MET Ex­on 14 dele­tion NS­CLC (Chi­na). [more in­for­ma­tion]
Impact Therapeutics Inc
IM­PACT Ther­a­peu­tics is a pri­vate­ly held clin­i­cal-stage bio­phar­ma­ceu­ti­cal com­pany and ded­i­cat­ed to the dis­cov­ery and de­vel­op­ment of tar­get­ed an­ti-can­cer ther­a­peu­tics based on syn­thet­ic lethal­i­ty. IM­P7068 is a nov­el Wee1 in­hibi­tor dis­cov­ered and de­vel­oped by IM­PACT Ther­a­peu­tics, with world­wide in­tel­lec­tu­al prop­er­ty, part of in-house DDR franchise. [more in­for­ma­tion]
IN8bio, Inc. [INAB] $113 MM MCap
IN­8bio, Inc. is the first com­pany to ad­vance ge­net­i­cal­ly-mod­i­fied gam­ma-del­ta T cells in­to clin­i­cal trials with its Del­tEx Plat­form, based on ex-vi­vo ex­pand­ed and ac­ti­vat­ed gam­ma-del­ta T cells. Two in­vesti­ga­tor-ini­ti­at­ed Phase 1 clin­i­cal trials are un­der­way for lead gam­ma-del­ta T cell prod­uct can­di­dates: INB-200 for the treat­ment of new­ly di­ag­nosed glioblas­to­ma (rapid­ly pro­gress­ing brain tu­mor) and INB-100 for the treat­ment of pa­tients with acute leukemia un­der­go­ing he­ma­topoi­et­ic stem cell tran­s­plan­ta­tion. [more in­for­ma­tion]
Iovance Biotherapeutics [IOVA] $4,125 MM MCap
Late-stage cell ther­a­py com­pany uti­l­iz­ing pro­pri­e­tary au­tol­o­gous tu­mor in­fil­trat­ing lym­pho­cytes (TILs) to at­tack solid tu­mors. The com­pany is con­duct­ing piv­o­tal stage trials in me­tastat­ic me­lano­ma and ad­vanced cer­vi­cal can­cer with BLAs ex­pect­ed 2020. [more in­for­ma­tion]
Junshi Biosciences [1877:HK]
Has a di­ver­si­fied R&D pipe­line com­pris­ing 21 drug can­di­dates with ther­a­peu­tic ar­eas cov­er­ing can­cer, metabolic, au­toim­mune, neu­ro­log­i­cal, and in­fec­tious dis­eas­es. Prod­uct types in­clude mon­o­clo­n­al anti­bodies, fu­sion pro­teins, anti­body-drug con­ju­gates, and small molecule drugs. With a com­bined 33,000L fer­men­ta­tion ca­pac­i­ty in two GMP-fa­cil­i­ties at Shang­hai and Suzhou. JS001, or tori­pal­imab, is ap­proved by the NM­PA and the first mar­ket­ed an­ti-PD-1 mAb anti­body self-de­vel­oped by a PRC com­pany. [more in­for­ma­tion]
KAHR
KAHR is de­vel­op­ing nov­el im­muno-on­col­o­gy fu­sion pro­teins. DSP107, is a CD47-41BB tar­get­ing com­pound aimed at tar­get­ing can­cer cells' in­nate de­fens­es and ac­ti­vat­ing lo­cal­ized re­sponse. Ac­ti­vat­ed path­ways in­clude in­nate and adap­tive im­mu­ni­ty. [more in­for­ma­tion]
Keros Therapeutics [KROS] $910 MM MCap
Our lead pro­tein ther­a­peu­tic prod­uct can­di­date, KER-050, is be­ing de­vel­oped for the treat­ment of cy­tope­nias, in­clud­ing ane­mia and throm­bo­cy­tope­nia, in pa­tients with myelodys­plas­tic syn­drome and myelo­fi­bro­sis. [more in­for­ma­tion]
Kintor Pharma [9939-hk]
Two Ph3s on­go­ing in Chi­na: Piv­o­tal monother­a­py and com­bo with abi­raterone and a Ph2 on­go­ing in US for mCR­PC (with breast and other AR-driv­en can­cers be­hind). Ad­di­tio­n­al pipe­line in­cludes a top­i­cal AR for alope­cia and ear­li­er-stage tar­gets in­clud­ing ALK-1 and hedge­hog. [more in­for­ma­tion]
Landos Biopharma [LABP] $599 MM MCap
Pipe­line tar­gets nov­el im­munometabolic path­ways, in­clud­ing LAN­CL2, NL­RX1 and PLXD­C2. Lead as­set omi­lan­cor is a nov­el, oral, gut-re­strict­ed small molecule ther­a­peu­tic can­di­date for the treat­ment of ul­cer­a­tive coli­tis (com­plet­ed Ph2), Crohn’s dis­ease (Ph2) and Eosinophil­ic Esophagi­tis that tar­gets the LAN­CL2 path­way [more in­for­ma­tion]
Lineage Cell Therapeutics Inc. [LCTX] $352 MM MCap
Cell ther­a­py com­pany with 3 clin­i­cal pro­grams 1) OpRe­gen, an RPE tran­s­plant ther­a­py in Ph1/2a de­vel­op­ment for the treat­ment of dry-AMD. 2) OPC1, an oli­go­den­dro­cyte pro­gen­i­tor cell ther­a­py for acute spi­nal cord in­juries with Or­phan and RMAT desig­na­tions. 3) VAC2, an al­lo­gene­ic can­cer im­munother­a­py of anti­gen-pre­sent­ing den­drit­ic cells cur­rent­ly in a Ph 1 for NS­CLC con­duct­ed by CRUK. [more in­for­ma­tion]
Marker Therapeutics [MRKR] $132 MM MCap
Fo­cused on de­vel­op­ing next-gen­er­a­tion T cell-based im­munother­a­pies for the treat­ment of he­ma­to­log­i­cal ma­lig­nan­cies and solid tu­mor in­di­ca­tions. Mark­er's cell ther­a­py tech­nol­o­gy is based on the se­lec­tive ex­pan­sion of non-en­gi­neered, tu­mor-spe­cif­ic T cells that rec­og­nize tu­mor as­so­ci­at­ed anti­gens and kill tu­mor cells ex­press­ing those tar­gets. [more in­for­ma­tion]
MiNA Therapeutics
Ver­satile, pro­pri­e­tary small ac­ti­vat­ing ri­bonu­cle­ic acid (saR­NA) ther­a­peu­tics plat­form and in­ter­nal pipe­line, ini­tial­ly fo­cus­ing on on­col­o­gy and rare dis­ease in­di­ca­tions. Pre­par­ing to ini­ti­ate ran­domized Ph2 study for lead saR­NA drug can­di­date MTL-CEB­PA com­bined with so­rafenib in se­cond line he­p­a­to­cel­lu­lar car­ci­no­ma. [more in­for­ma­tion]
Monte Rosa Therapeutics [GLUE] $983 MM MCap
Next-gen­er­a­tion molec­u­lar glue-based tar­get­ed pro­tein degra­da­tion plat­form de­vel­op­ing small molecule ther­a­peu­tics that se­lec­tive­ly de­grade dis­ease-caus­ing pro­teins. Tar­get­ing the un­drug­gable pro­teome in on­col­o­gy and non-on­col­o­gy in­di­ca­tions via AI based de­gron pre­dic­tion. Ex­ten­sive in vi­vo da­ta to date has de­mon­s­trat­ed po­tent an­ti-tu­mor ac­tiv­i­ty. Lead pro­gram fo­cused on GSP­T1, a key reg­u­la­tor and vul­n­er­a­bil­i­ty of Myc-in­duced trans­la­tio­n­al ad­dic­tion. DC se­lec­tion for lead pro­gram ex­pect­ed in 2021. [more in­for­ma­tion]
Neoleukin Therapeutics [NLTX] $306 MM MCap
Lead prod­uct can­di­date, NL-201, is a de no­vo pro­tein de­signed to mim­ic the ther­a­peu­tic ac­tiv­i­ty of IL-2 and IL-15 for the treat­ment of can­cer. NL-201 is de­signed to elim­i­nate bind­ing to the al­pha sub­u­nit of the IL-2/CD25 re­cep­tor while main­tain­ing high-affini­ty bind­ing to the be­ta and gam­ma sub­u­nits. [more in­for­ma­tion]
NexImmune, Inc. [NEXI] $290 MM MCap
Mul­ti-anti­gen-spe­cif­ic T cell ther­a­py. Syn­thet­ic nano­par­ti­cles de­c­o­rat­ed w a com­bo of mul­ti­ple tu­mor rel­e­vant anti­gens and co-sti­m­u­la­to­ry sig­nals en­gag­ing di­rect­ly w tar­get­ed T cells. Two Ph 1's on­go­ing. [more in­for­ma­tion]
NorthSea Therapeutics
First-in class, oral, struc­tu­ral­ly en­gi­neered fat­ty acids [SE­FAs] ad­dress­ing NASH (pos­i­tive Ph2b in­ter­im re­sults) and as­so­ci­at­ed metabolic di­s­or­ders via unique tar­get­ing of path­ways reg­u­lat­ing metabolism, oxida­tive stress, in­flam­ma­tion, and fi­bro­sis. $40m Se­ries B (Jan 2020) with ven­Bio Part­n­ers (lead) and Sofin­no­va In­vest­ments. [more in­for­ma­tion]
Novavax AB [NVAX] $12,063 MM MCap
Clin­i­cal-stage vaccine com­pany lev­er­ag­ing re­com­bi­nant nano­par­ti­cle tech­nol­o­gy plat­form to ad­dress a broad range of in­fec­tious dis­eas­es. NVX-CoV­2373, lead vaccine can­di­date against SARS-CoV-2 is be­ing eval­u­at­ed in two piv­o­tal Ph 3 trials [more in­for­ma­tion]
Oncorus [ONCR] $247 MM MCap
The com­pany's lead pro­gram ON­CR-177 is a Ph1 oHSV with com­ple­men­tary pay­loads (PD1, CCL4, IL12, FLT3, CT­LA4) to en­cour­age im­mune sti­m­u­la­tion, with read­out guid­ed for 2H21. [more in­for­ma­tion]
OnKure Therapeutics, Inc.
De­vel­op­ing epi­ge­net­ic can­cer ther­a­pies in­clud­ing HDAC in­hibi­tors. Lead as­set OKI-179 is a class 1 HDAC in­hibi­tor in Ph 1. [more in­for­ma­tion]
Photocure ASA [PHO:OS] NKr3,097 MM MCap
Rev­enue-gen­er­at­ing urol­o­gy-fo­cused com­pany. Lead prod­uct, Hexvix®/Cysview® im­proves de­tec­tion of blad­der can­cer un­der blue light cys­tos­copy (BLC), which can re­duce dis­ease re­cur­rence and pro­gres­sion rates. Hexvix®/Cysview® is in­clud­ed in clin­i­cal consen­sus guide­lines and re­mains on a strong growth path. Rev­enues in 2020 to­taled $31M. Re­cent­ly suc­cess­ful­ly launched the Eu­ro­pean Hexvix op­er­a­tions, con­soli­dat­ing the Com­pany’s prod­uct franchise glob­al­ly. [more in­for­ma­tion]
Protagonist Therapeutics [PTGX] $1,473 MM MCap
Pro­pri­e­tary pep­tide tech­nol­o­gy plat­form to de­vel­op oral tar­get­ed ther­a­py-based drugs and in­jecta­bles for rare dis­eas­es. PTG-300 in­jectable hep­cidin mimet­ic Ph 2 trials on­go­ing in po­ly­cythemia ve­ra and hered­i­tary he­mochro­ma­to­sis; pos­i­tive up­dat­ed Ph 2 re­sults in PV pre­sent­ed at ASH 2020. PN-943 oral GI-re­strict­ed al­pha-4-be­ta-7 an­ta­g­on­ist Ph 2 in ul­cer­a­tive coli­tis study sites ac­ti­vat­ed; PTG-200, part­nered w/ Janssen, oral GI-re­strict­ed IL-23R an­ta­g­on­ist Ph 2 Crohn’s dis­ease study on­go­ing. [more in­for­ma­tion]
Ryvu Therapeutics [RVU:WAR]
De­vel­op­er of tar­get­ed on­col­o­gy ther­a­pies in­clud­ing he­ma­tol­o­gy/solid tu­mors. RVU120 is whol­ly-owned first-in-class oral CD­K8/19 in­hibi­tor in Phase I for AML/MDS Small molecule, syn­thet­ic lethal­i­ty plat­form in pre-clin­i­cal de­vel­op­ment in­clud­ing nov­el tar­gets WRN and PRMT5. [more in­for­ma­tion]
Savara Inc. [SVRA] $147 MM MCap
Clin­i­cal-stage bio­phar­ma fo­cused on rare re­s­pi­ra­to­ry dis­eas­es; mol­gra­mos­tim, an in­haled gran­u­lo­cyte-macrophage colony-sti­m­u­lat­ing fac­tor (GM-CSF), is in Phase 3 de­vel­op­ment for the treat­ment of au­toim­mune pul­mo­nary alve­o­lar pro­tei­no­sis (aPAP); top-line da­ta from the dou­ble-blind pe­ri­od of the Com­pany’s Phase 3 trial (IM­PALA 2) is an­ti­ci­pat­ed at the end of 2Q 2024. [more in­for­ma­tion]
Secarna Pharmaceuticals GmbH
Se­car­na's unique­ly ef­fi­cient LNA­plus™ dis­cov­ery pro­cess is fu­eled by their pro­pri­e­tary and stream­lined Oli­go­fy­er™ bioin­for­mat­ics sys­tems large in-house cell li­brary and own in vit­ro screen­ing as­says. [more in­for­ma­tion]
Sigilon Therapeutics, Inc. [SGTX] $178 MM MCap
5 INDs exp in the next 2 years; 1st IND in Jan 2020 (He­mophilia A). Eli Lil­ly col­lab­o­ra­tion in T1D ($75m ini­tial com­mit­ment, $410 mile­s­tones & sin­gle to dou­ble dig­it roy­al­ties). En­gi­neer­ing cells to pro­duce cru­cial pro­teins/en­zymes/etc; en­cap­su­late cells in al­gi­nate sphere co­va­lent­ly bond­ed w/coat­ing that pre­vents fi­bro­sis & re­jec­tion; [more in­for­ma­tion]
Sonnet Biotherapeutics, Inc. [SONN] $38 MM MCap
Son­net's in­ter­leukin-based can­di­date has been shown to en­hance pK (up to 10 fold) and im­prove tu­mor de­liv­ery with an in­crease in in vi­vo ef­fi­ca­cy (30 fold) as de­mon­s­trat­ed in a mice tu­mor mod­el. The Son­net plat­form de-risks the use of in­ter­leukins by great­ly ex­tend­ing their in vi­vo half-life, while al­so im­prov­ing their spe­ci­fic­i­ty to tu­mor tis­sue. [more in­for­ma­tion]
Spruce Biosciences [SPRB] $105 MM MCap
The com­pany’s lead prod­uct can­di­date, til­dac­er­font, is an in­vesti­ga­tio­n­al oral drug that is be­ing eval­u­at­ed in studies for the treat­ment of con­geni­tal adre­nal hy­per­pla­sia (CAH). The com­pany al­so plans to eval­u­ate til­dac­er­font in other dis­eas­es im­pact­ed by el­e­vat­ed ACTH or adre­nal an­dro­gens in­clud­ing Pe­di­a­tric CAH and Po­ly­cys­tic Ovary Syn­drome (PCOS). [more in­for­ma­tion]
Strongbridge Biopharma [SBBP] $136 MM MCap
Rare dis­eas­es; Keveyis for PPP revs ~21.7M for 2019 and $26 - $27M for 2020. Re­cor­lev for en­doge­nous Cush­ing's syn­drome Ph 3 pub­lished with to­p­line place­bo-con­trolled Ph 3 3Q20. [more in­for­ma­tion]
Sutro Biopharma [STRO] $876 MM MCap
FolR&al­pha;-tar­get­ing ADC (STRO-002) Phase 1, an­ti­ci­pat­ed pre­lim­i­nary da­ta in ovarian can­cer and EOP1/2 FDA meet­ing in 2H21. CD74-tar­get­ing ADC (STRO-001) Phase 1 dose-ex­pan­sion to be ini­ti­at­ed in 2H21. Pre-clin­i­cal da­ta and IND pro­jec­tions for STRO-003 in gen­er­al can­cer an­ti­ci­pat­ed for 2H21. BMS col­lab­o­ra­tion for CC-99712 (BC­MA-tar­get­ing ADC) grant­ed or­phan drug desig­na­tion in Fe­bruary 21. IND-en­abling tox ini­ti­at­ed for Mer­ck col­lab­o­ra­tion on a cy­tokine deri­va­tive pro­gram. [more in­for­ma­tion]
Syneos Health [SYNH] $9,077 MM MCap
Sy­neos Health® is an end-to-end, ful­ly in­te­grat­ed bio­phar­ma­ceu­ti­cal so­lu­tions com­pany that works dif­fer­ent­ly. At Sy­neos Health, all the dis­ci­p­lines in­volved in bring­ing new ther­a­pies to mar­ket, from clin­i­cal to com­mer­cial, work to­gether to cre­ate cus­tomer suc­cess. Our unique Bio­phar­ma­ceu­ti­cal Ac­cel­er­a­tion Mod­el de­liv­ers val­ue across the small to mid-size to large cus­tomer cont­in­u­um. [more in­for­ma­tion]
Tessa Therapeutics
On­go­ing Ph III (na­sopha­ryn­geal can­cer), up­com­ing piv­o­tal Ph II (Hodgkin lym­pho­ma), and mul­ti­ple other clin­i­cal-stage pro­grams. GMP fa­cil­i­ty un­der con­struc­tion. Key col­lab­o­ra­tions: Bay­lor, Park­er Inst., St. Jude Chil­dren’s, and JV in Chi­na. [more in­for­ma­tion]
Treos Bio Limited
Pipe­line in­cludes per­so­n­al­ized + off-the-shelf ther­a­pies for mul­ti­ple solid can­cers and an IND-ready 2nd gen­er­a­tion COVID T-cell vaccine. Their lead pro­grams in­clude treat­ment for MSS col­orec­tal can­cer, with strong Ph1/2 re­sults, and clin­i­cal col­lab­o­ra­tions with Roche and Mayo Clin­ic. [more in­for­ma­tion]
Tryp Therapeutics [TRYPF] $23 MM MCap
Tryp Ther­a­peu­tics Inc is a phar­ma­ceu­ti­cal com­pany fo­cused on iden­ti­fy­ing and de­vel­op­ing clin­i­cal-stage com­pounds for or­phan dis­eas­es and other dis­eas­es with high un­met med­i­cal needs. The com­pany's main de­vel­op­ment pro­gram PFN pro­gram, is de­signed to treat neu­ropsychi­a­tric di­s­or­ders through the dos­ing of for­mu­la­tions of syn­thet­ic psilo­cy­bin. [more in­for­ma­tion]
Vaccitech Plc [VACC] $503 MM MCap
Pro­pri­e­tary ChA­dOx (prime) and MVA (boost) tech­nol­o­gy plat­form in­duces and main­tains CD8+ T-cells at the max­i­mum lev­els pub­lished to date. Ph1/2 da­ta for HPV and HBV im­munother­a­pies ex­pect­ed 2H20. En­cour­ag­ing pros­tate can­cer, 5T4 im­munother­a­peu­tic da­ta re­cent­ly re­leased. Ph1/2 NS­CLC MAGE-NYE­SO im­munother­a­peu­tic en­ters clin­ic in Q1 2021. ChA­dOx COVID-19 vaccine out-li­censed to Ox­ford Uni/As­traZene­ca with post-pan­dem­ic rev­enue stream. $150M fund­ing at Jen­n­er In­sti­tute and com­pany raised $48M since for­ma­tion [more in­for­ma­tion]
Verrica Pharmaceuticals [VRCA] $368 MM MCap
Ver­ri­ca Phar­ma­ceu­ti­cals is a der­ma­tol­o­gy ther­a­peu­tics com­pany de­vel­op­ing med­i­ca­tions for vi­ral skin dis­eas­es re­quir­ing med­i­cal at­ten­tion. Lead prod­uct, VP-102 for mol­lus­cum con­ta­gio­sum has a PD­U­FA date of Ju­ly 13, 2020. Phase 2 da­ta in ex­ter­nal geni­tal warts ex­pect­ed in 2H20. Ini­ti­a­tion of Phase 3 in com­mon warts in 1H20 and ini­ti­a­tion of Phase 2 in plan­tar warts in mid-2020. [more in­for­ma­tion]
Vivoryon [VVY]
Vivo­ry­on Ther­a­peu­tics is fo­cused on nov­el small molecule in­hibi­tors of glu­taminyl cy­clase (QPCT) de­signed to pre­vent the for­ma­tion of patho­log­i­cal­ly al­tered pro­teins be­fore they cause ir­re­v­ersi­ble da­m­age. Lead can­di­date varog­lu­tam­s­tat, cur­rent­ly in Phase 2 in Alzheimer’s dis­ease (AD), tar­gets all three ma­jor hall­marks of AD. [more in­for­ma­tion]
XOMA Corporation [XOMA] $292 MM MCap
Biotech roy­al­ty and mile­s­tone ag­gre­ga­tor with port­fo­lio of 70+ as­sets in >30 dis­closed in­di­ca­tions where R&D costs are borne by part­n­ers e.g. No­var­tis’s Is­cal­imab (CFZ533) an­ti-CD40 mAb in Ph2. [more in­for­ma­tion]
Zentalis [ZNTL] $3,374 MM MCap
Dis­cov­er­ing and de­vel­op­ing small molecule ther­a­peu­tics tar­get­ing fun­da­men­tal bi­o­log­i­cal path­ways of can­cers. Broad pipe­line of po­ten­tial­ly best-in-class on­col­o­gy can­di­dates, in­clud­ing ZN-c3, a WEE1 in­hibi­tor, ZN-c5, an oral se­lec­tive es­tro­gen re­cep­tor de­grad­er for ER+/HER2- breast can­cer, ZN-d5, a BCL-2 in­hibi­tor and ZN-e4, an EGFR in­hibi­tor. [more in­for­ma­tion]