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Evox Therapeutics: Evox Therapeutics is a privately held, Oxford-based biotechnology company focused on harnessing and engineering the natural delivery capabilities of extracellular vesicles, known as exosomes, to develop an entirely new class of therapeutics. Backed by leading life sciences venture capital groups and supported by a comprehensive intellectual property portfolio, Evox’s mission is to positively impact human health by creating novel exosome-based therapeutics for the treatment of various severe diseases with limited options for patients and their families. Evox has created substantial proprietary technology to modify exosomes using various molecular engineering, drug loading, and targeting strategies to facilitate targeted drug delivery to organs of interest, including the brain and the central nervous system. Exosome-based drugs have the potential to address some of the limitations of protein, antibody and nucleic acid-based therapies by enabling delivery to cells and tissues that are currently out of reach using other drug delivery technologies, and Evox is leading the development within this emerging therapeutic space.
Autoimmune, Central Nervous System
Cell Therapy, Gene Therapy
2nd Floor East Building
Oxford, Oxfordshire OX4 4HG
Oxford, Oxfordshire OX4 4HG
Company Participants at 2020 Wall Street "On Tap"
Antonin De Fougerolles
Evox Therapeutics, Chief Executive Officer
Tony has over 20 years of biotech R&D experience in building out drug pipelines, and he has played a key role in developing and successfully advancing 3 new drug modalities towards the market (RNAi, modified mRNA, single domain antibodies) and in helping build several multi-billion dollar companies from start-up stage. Prior to joining Evox, Tony was CSO of Ablynx, where he led the company’s non-clinical R&D operations, including Discovery, Pharmacology, CMC, and Clinical Trial Drug Supply, and played a key role in the approval of the 1st single domain antibody drug, caplacizumab. Prior to Ablynx, Tony was founding CSO at Moderna Therapeutics pioneering modified mRNA as a new therapeutic modality for both rare diseases and as vaccines, CSO of antibody-based immuno-oncology company Tolerx Inc, and VP Research at Alnylam where he helped develop RNAi as a new therapeutic modality, including overseeing the development of the now 1st approved RNAi delivery system, and the development of several RNAi drugs including inclisiran. Also, Tony has been Principal Investigator on over $80m in grants, has over 60 scientific publications, and is an inventor on over 100 issued U.S. patents. He also serves on the Scientific Advisory Boards of MiNA Therapeutics and LIfT BioSciences. Tony earned his Ph.D. in Immunology from Harvard University.