Affimed N.V.: Proprietary ROCK® platform enabling generation of multi-specific antibodies is basis for its collaboration with Genentech ($96M upfront / $5B potential) to develop NK-cell engager-based therapeutics. Pipeline includes NK cell engager AFM13 (CD30/CD16A) to enter Ph 2 registration study in CD30-positive PTCL and an investigator-sponsored study by MDACC of AFM13 combined with allogeneic NK cells in relapsed/refractory CD30-positive lymphoma. IND cleared for AFM24, the company’s innate cell engager that targets EGFR-expressing solid tumors.
Based in...
Europe, USA
Clinical Stage
Phase l or ll
Disease Space
Hematology, Immuno-Oncology, Oncology
Public, USA
Market Cap
100MM - 500MM
Therapeutic Modalities
Antibodies, Platform Technology
Im Neuenheimer Feld 582
Heidelberg, Baden-Wurttemberg 69120

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Lead Programs


Disease Target CD30 Immune Cell Target CD16A

Indication Phase
Hodgkin lymphoma + PD-1 1
Hodgkin lymphoma 2
Hodgkin lymphoma + adoptive NK cells Pre-clinical
CD30-positive lymphoma 2


Disease Target EGFRwt Immune Cell Target CD16A

Indication Phase
Solid tumors Pre-clinical

Top 10 Holders of Affimed N.V.

Institution OS (%) Position Mkt Val ($MM) Source Filing Date
NEA Management Co. 9.81 6,126,488 23.28 13F 2020-03-31
Millennium Management LLC 7.41 4,625,033 17.58 Stakes 2020-05-18
BlackRock Fund Advisors 5.07 3,164,961 12.03 13F 2020-03-31
Stonepine Capital Management LLC 4.81 3,000,000 11.40 13F 2020-03-31
Bain Capital Public Equity Management II LLC 3.66 2,283,428 8.68 13F 2020-03-31
Point72 Asset Management LP (Old) 2.72 1,700,000 6.46 13F 2020-03-31
683 Capital Management LLC 2.40 1,500,000 5.70 13F 2020-03-31
Fidelity Management & Research Co. LLC 2.04 1,276,276 4.85 13F 2020-03-31
State Street Corp. 1.91 1,190,695 4.52 13F 2020-03-31
DAFNA Capital Management LLC 1.82 1,133,401 4.31 13F 2020-03-31
Ownership data is sourced through FactSet.

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